{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:35Z","timestamp":1792801475042,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"],"award-info":[{"award-number":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"],"award-info":[{"award-number":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["PCB\u2010106"],"award-info":[{"award-number":["PCB\u2010106"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent evidence indicates that lipophilic statins have a neuroprotective benefit in animal models of Parkinson's disease (PD). The objective of this study was to evaluate whether lovastatin has the potential to slow motor symptom progression in patients with early\u2010stage PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This double\u2010blind, randomized, placebo\u2010controlled trial enrolled 77 patients with early\u2010stage PD between May 23, 2017, and July 12, 2018, with follow\u2010up ending September 1, 2019. Lovastatin 80\u2009mg\/day or placebo with 1:1 randomization was administered for 48\u2009weeks. Mean change in the parts I\u2013III scores of the Movement Disorder Society\u2013Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS), changes in the striatal dopamine uptake ratio measured by\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopa PET scan, and changes in PD medications between baseline and the week 48 visit were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 77 randomized patients, 70 (90.9%) completed the study. There was a slightly beneficial trend of the MDS\u2010UPDRS motor score in the lovastatin group (\u22123.18\u00a0\u00b1\u20095.50) compared with the placebo group (\u22120.50\u2009\u00b1\u20096.11);\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.14 adjusted for age, sex, disease duration, and baseline LEDD. Mean percentage change in the striatal\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopa uptake ratio deteriorated less in the lovastatin group than in the placebo group on the dominant side of caudate (1.2%\u2009\u00b1\u20097.3% vs \u22127.1%\u2009\u00b1\u20098.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and putamen (2.3%\u2009\u00b1\u20097.1% vs \u22126.4%\u2009\u00b1\u20098.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). We found no between\u2010group differences in the change in part I or part II MDS\u2010UPDRS scores. Lovastatin was generally well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lovastatin treatment in patients with early\u2010stage PD was associated with a trend of less motor symptom worsening and was well tolerated. A future larger long\u2010term follow\u2010up study is needed to confirm our findings. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28474","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T19:03:15Z","timestamp":1610737395000},"page":"1229-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A\n                    <scp>Double\u2010Blind<\/scp>\n                    , Randomized, Controlled Trial of Lovastatin in\n                    <scp>Early\u2010Stage<\/scp>\n                    Parkinson's Disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7573","authenticated-orcid":false,"given":"Chin\u2010Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital  Taipei 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