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It followed MDSGene's standardized data extraction protocol and screened a total of ~1200 citations. Phenotypic and genotypic data on ~1200 patients with 254 different mutations were curated and analyzed. There were differences regarding age at onset, site of onset, and distribution of symptoms across mutation carriers in all 7 genes. Although carriers of\n                    <jats:italic>TOR1A<\/jats:italic>\n                    ,\n                    <jats:italic>THAP1<\/jats:italic>\n                    ,\n                    <jats:italic>PRKRA<\/jats:italic>\n                    ,\n                    <jats:italic>KMT2B<\/jats:italic>\n                    , or\n                    <jats:italic>HPCA<\/jats:italic>\n                    mutations mostly showed childhood and adolescent onset, patients with\n                    <jats:italic>GNAL<\/jats:italic>\n                    and\n                    <jats:italic>ANO3<\/jats:italic>\n                    mutations often developed first symptoms in adulthood.\n                    <jats:italic>GNAL<\/jats:italic>\n                    and\n                    <jats:italic>KMT2B<\/jats:italic>\n                    mutation carriers frequently have 1 predominant site of onset, that is, the neck (\n                    <jats:italic>GNAL<\/jats:italic>\n                    ) or the lower limbs (\n                    <jats:italic>KMT2B<\/jats:italic>\n                    ), whereas site of onset in DYT\u2010\n                    <jats:italic>TOR1A<\/jats:italic>\n                    , DYT\u2010\n                    <jats:italic>THAP1<\/jats:italic>\n                    , DYT\u2010\n                    <jats:italic>ANO3<\/jats:italic>\n                    , DYT\u2010\n                    <jats:italic>PRKRA<\/jats:italic>\n                    , and DYT\u2010\n                    <jats:italic>HPCA<\/jats:italic>\n                    was broader. However, in most DYT\u2010\n                    <jats:italic>THAP1<\/jats:italic>\n                    and DYT\u2010\n                    <jats:italic>ANO3<\/jats:italic>\n                    patients, dystonia first manifested in the upper half of the body (upper limb, neck, and craniofacial\/laryngeal), whereas onset in DYT\u2010\n                    <jats:italic>TOR1A<\/jats:italic>\n                    , DYT\u2010\n                    <jats:italic>PRKRA<\/jats:italic>\n                    and DYT\u2010\n                    <jats:italic>HPCA<\/jats:italic>\n                    was frequently observed in an extremity, including both upper and lower ones. For\n                    <jats:italic>ANO3<\/jats:italic>\n                    , a segmental\/multifocal distribution was typical, whereas\n                    <jats:italic>TOR1A<\/jats:italic>\n                    ,\n                    <jats:italic>PRKRA<\/jats:italic>\n                    ,\n                    <jats:italic>KMT2B<\/jats:italic>\n                    , and\n                    <jats:italic>HPCA<\/jats:italic>\n                    mutation carriers commonly developed generalized dystonia.\n                    <jats:italic>THAP1<\/jats:italic>\n                    mutation carriers presented with focal, segmental\/multifocal, or generalized dystonia in almost equal proportions.\n                    <jats:italic>GNAL<\/jats:italic>\n                    mutation carriers rarely showed generalization. This review provides a comprehensive overview of the current knowledge of hereditary isolated dystonia. The data are also available in an online database (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.mdsgene.org\">http:\/\/www.mdsgene.org<\/jats:ext-link>\n                    ), which additionally offers descriptive summary statistics. \u00a9 2021 The Authors.\n                    <jats:italic>Movement Disorders<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.28485","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T08:09:44Z","timestamp":1611734984000},"page":"1086-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Genotype\u2013Phenotype Relations for Isolated Dystonia Genes:\n                    <scp>MDSGene<\/scp>\n                    Systematic 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