{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:42:44Z","timestamp":1778802164457,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. 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GD patients display altered peripheral immune proteins. However, it is unknown if these are altered in <jats:italic>GBA<\/jats:italic> carriers with PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether plasma cytokines and immune biomarkers associated with GD are also altered in <jats:italic>GBA<\/jats:italic> carriers with or without PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inflammatory cytokines and established GD biomarkers, ferritin, CD162, CCL18, and chitotriosidase (28 biomarkers) were measured in <jats:italic>GBA<\/jats:italic> pathogenic variant carriers with (n\u00a0=\u00a0135) and without (n\u00a0=\u00a083) PD, and non\u2010carriers with (n\u00a0=\u00a075) and without PD (n\u00a0=\u00a077).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD patients with biallelic pathogenic variants in <jats:italic>GBA<\/jats:italic> had elevated plasma levels of ferritin, CCL18, and MIP1\u03b1. These biomarkers were not elevated in heterozygous <jats:italic>GBA<\/jats:italic> carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GD plasma biomarkers are not promising candidates for stratifying the risk for PD in carriers of heterozygous <jats:italic>GBA<\/jats:italic> pathogenic variants. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28525","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T21:32:09Z","timestamp":1613251929000},"page":"1451-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers with and Without Parkinson 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