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Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta\u2010analysis followed the MOOSE guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 11.91\u2009years of follow\u2010up (mean =\u00a08.88\u2009years; 4,360,105 person\u2010years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR\u00a0=\u00a01.28; 95% CI: 1.21\u20131.36) and categorical variable (top vs. bottom quartiles: HR\u00a0=\u00a01.88; 95% CI: 1.60\u20132.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5\u2009years of follow\u2010up. The associations were similar for women and men and across levels of socioeconomic status. Random\u2010effect meta\u2010analysis of four prospective studies (N\u00a0=\u00a0548,284) found neuroticism associated with increased risk of incident PD (HR\u00a0=\u00a01.82; 95% CI: 1.59\u20132.08; <jats:italic>P<\/jats:italic>\u00a0=\u00a07.31<jats:sup>\u221219<\/jats:sup>). There was no evidence of heterogeneity across studies with follow\u2010ups ranging from one to four decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results from the large UK Biobank and meta\u2010analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28575","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:02:31Z","timestamp":1617580951000},"page":"1863-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Neuroticism and Risk of Parkinson's Disease: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-8885","authenticated-orcid":false,"given":"Antonio","family":"Terracciano","sequence":"first","affiliation":[{"name":"Department of Geriatrics Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damaris","family":"Aschwanden","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Stephan","sequence":"additional","affiliation":[{"name":"Euromov University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cerasa","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research and Innovation, National Research Council (IRIB\u2010CNR)  Mangone Italy"},{"name":"S. Anna Institute  Crotone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-0615","authenticated-orcid":false,"given":"Luca","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge United Kingdom"},{"name":"Istituto di Bioimmagini e Fisiologia Molecolare (IBFM) Consiglio Nazionale delle Ricerche (CNR)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Toschi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine &amp; Prevention University \u201cTor Vergata\u201d  Rome Italy"},{"name":"A.A. 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