{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:40:07Z","timestamp":1791430807310,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["26\/2014"],"award-info":[{"award-number":["26\/2014"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2008\/09009\u20102"],"award-info":[{"award-number":["2008\/09009\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>REM sleep behaviour disorder (RBD) is a common non\u2010motor feature of Parkinson\u2019s disease (PD). Cannabidiol (CBD) is one of the main non\u2010psychoactive components of Cannabis sativa and may represent an alternative route for treating RBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed the efficacy and safety of CBD for RBD in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a phase II\/III, double\u2010blind, placebo\u2010controlled clinical trial in 33 patients with RBD and PD. Patients were randomized 1:1 to CBD in doses of 75 to 300mg or matched capsules placebo and were followed up for 14 weeks. The primary outcomes were the frequency of nights with RBD, CGI\u2010I, and CGI\u2010S.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CBD showed no difference to placebo for primary outcomes. Regarding secondary outcomes, we observed a significant improvement in average sleep satisfaction from the 4th to 8th week in the CBD versus placebo group with <jats:italic>P<\/jats:italic> = 0.049 and <jats:italic>P<\/jats:italic> = 0.038, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBD, as an adjunct therapy, showed no reduction in RBD manifestations in PD patients. A transient improvement in sleep satisfaction with a dose of 300mg has been noted. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28577","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T21:58:42Z","timestamp":1616450322000},"page":"1711-1715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-6477","authenticated-orcid":false,"given":"Carlos M.O.","family":"de Almeida","sequence":"first","affiliation":[{"name":"School of Health Sciences State University of Amazonas  Manaus, Amazon Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuelina M.C.","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Sciences 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Ribeir\u00e3o Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.","family":"Zuardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Sciences of Behavior, Division of Neurology, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"National Institute of Science and Technology in Translational Medicine, CNPq \/FAPESP\/CAPES  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.S.","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Sciences of Behavior, Division of Neurology, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"National Institute of Science and Technology in Translational Medicine, CNPq \/FAPESP\/CAPES  S\u00e3o Paulo 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