{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:45:40Z","timestamp":1793475940641,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary orthostatic tremor (POT) is a rare disorder, characterized by 13 to 18\u2009Hz tremor in the legs when standing and is often refractory to medical treatment. Epidural spinal cord stimulation has been proposed as an alternative treatment. However, this approach is invasive, which limits its application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Trans\u2010spinal direct current stimulation (tsDCS) is a non\u2010invasive method to modulate spinal cord circuits. The aim of this proof\u2010of\u2010concept study was to investigate the potential beneficial effect of tsDCS in POT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a double\u2010blind, sham\u2010controlled study in 16 patients with POT. In two separate visits, patients received sham tsDCS first followed by active (either cathodal or anodal) tsDCS. The primary outcome was the change in time in standing position. Secondary outcomes comprised quantitative assessment of tremor, measurement of corticospinal excitability including short\u2010latency afferent inhibition, and clinical global impression\u2010improvement (CGI\u2010I). Measurements were made at baseline, after sham tsDCS, 0\u201330 min, and 30\u201360\u2009min after active conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cathodal\u2010tsDCS reduced tremor amplitude and frequency and lowered corticospinal excitability whereas anodal\u2010tsDCS reduced tremor frequency only. CGI\u2010I scores positively correlated with the time in standing position after both active tsDCS conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single session of tsDCS can improve instability in POT. This opens a new vista for experimental treatment options using multiple sessions of spinal DC stimulation. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28581","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T08:21:02Z","timestamp":1616833262000},"page":"1835-1842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Trans\u2010Spinal Direct Current Stimulation for Managing Primary Orthostatic Tremor"],"prefix":"10.1002","volume":"36","author":[{"given":"Jean\u2010Charles","family":"Lamy","sequence":"first","affiliation":[{"name":"Institut du Cerveau \/ Paris Brain Institute, ICM, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re, CNRS UMR 7225, Inserm U 1127, Sorbonne Universit\u00e9 UM75  Paris 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