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In addition, a majority of the reports focused on Europeans, lacking evidence on other populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study is to elucidate the genetic features of the MHC region associated with PD risk in trans\u2010ethnic cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted trans\u2010ethnic fine\u2010mapping of the MHC region for European populations (14,650 cases and 1,288,625 controls) and East Asian populations (7712 cases and 27,372 controls). We adopted a hybrid fine\u2010mapping approach including both HLA genotype imputation of genome\u2010wide association study (GWAS) data and direct imputation of HLA variant risk from the GWAS summary statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Through trans\u2010ethnic MHC fine\u2010mapping, we identified the strongest associations at amino acid position 13 of HLA\u2010DR\u03b21 (<jats:italic>P<\/jats:italic>\u00a0=\u20096.0\u2009\u00d7\u200910<jats:sup>\u221215<\/jats:sup>), which explains the majority of the risk in <jats:italic>HLA\u2010DRB1<\/jats:italic>. In silico prediction revealed that <jats:italic>HLA\u2010DRB1<\/jats:italic> alleles with histidine at amino acid position 13 (His13) had significantly weaker binding affinity to an \u03b1\u2010synuclein epitope than other alleles (<jats:italic>P<\/jats:italic>\u00a0=\u20099.6\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>). Stepwise conditional analysis suggested additional independent associations at Ala69 in HLA\u2010B (<jats:italic>P<\/jats:italic>\u00a0=\u20091.0\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>). A subanalysis in Europeans suggested additional independent associations at non\u2010HLA genes in the class III MHC region (<jats:italic>EHMT2<\/jats:italic>; <jats:italic>P<\/jats:italic>\u00a0=\u20092.5\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study highlights the shared and distinct genetic features of the MHC region in patients with PD across ethnicities. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28583","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T12:45:16Z","timestamp":1620737116000},"page":"1805-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Trans\u2010Ethnic Fine\u2010Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-4600","authenticated-orcid":false,"given":"Tatsuhiko","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Statistical Genetics Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Neurology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Neurology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-3593","authenticated-orcid":false,"given":"Ken","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Pharmaceutical Discovery Research Laboratories Teijin Pharma Limited  Hino Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-2308","authenticated-orcid":false,"given":"Jia Nee","family":"Foo","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore  Singapore Singapore"},{"name":"Human Genetics, Genome Institute of Singapore, A*STAR  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng\u2010King","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute Singapore General Hospital  Singapore Singapore"},{"name":"Duke\u2010National University of Singapore Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8472","authenticated-orcid":false,"given":"Yukinori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Laboratory of Statistical Immunology, Immunology Frontier 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