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Choosing among these treatments is influenced by scientific evidence, clinical expertise, and patient preferences. To foster patient engagement in decision\u2010making among the options, scientific evidence should be adjusted to their information needs. We conducted a systematic review from the patient perspective. First, patients selected outcomes for a treatment choice: quality of life, activities of daily living, ON and OFF time, and adverse events. Second, we conducted a systematic review and meta\u2010analysis for each treatment versus best medical treatment using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Finally, the evidence was transformed into comprehensible and comparable information. We converted the meta\u2010analysis results into the number of patients (per 100) who benefit clinically from an advanced treatment per outcome, based on the minimal clinically important difference and the cumulative distribution function. Although this approach allows for a comparison of outcomes across the three device\u2010aided therapies, they have never been compared directly. The interpretation is hindered by the relatively short follow\u2010up time in the included studies, usually less than 12\u2009months. These limitations should be clarified to patients during the decision\u2010making process. This review can help patients integrate the evidence with their own preferences, and with their clinician's expertise, to reach an informed decision. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.28599","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T07:59:21Z","timestamp":1617350361000},"page":"1293-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Translating Evidence to Advanced Parkinson's Disease Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-8650","authenticated-orcid":false,"given":"Frouke A.P.","family":"Nijhuis","sequence":"first","affiliation":[{"name":"Department of Neurology Canisius Wilhelmina Hospital  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