{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:08:24Z","timestamp":1792624104093,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006599","name":"Focused Ultrasound Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of magnetic resonance\u2010guided focused ultrasound (MRgFUS) thalamotomy for the treatment of focal hand dystonia (FHD) is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to prospectively investigate the efficacy of MRgFUS thalamotomy for the treatment of FHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed MRgFUS thalamotomy of the ventro\u2010oral (Vo) nucleus in 10 patients with FHD. We evaluated the scores of the Writer's Cramp Rating Scale (WCRS, 0\u201330; higher scores indicating greater severity), Tubiana Musician's Dystonia Scale (TMDS, 0\u20135; lower scores indicating greater severity), and Arm Dystonia Disability Scale (ADDS, 0%\u2013100%; lower scores indicating greater disability) at baseline and 3 and 12\u2009months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WCRS, TMDS, and ADDS scores significantly improved from 6.3\u2009\u00b1\u20092.7, 1.4\u2009\u00b1\u20090.5, and 58.7%\u2009\u00b1 14.3% at baseline to 1.6\u2009\u00b1\u20093.1 (<jats:italic>P<\/jats:italic>\u2009=\u20090.011), 5.0\u2009\u00b1\u20090 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001), and 81.6%\u2009\u00b1\u200922.9% (<jats:italic>P<\/jats:italic>\u2009=\u20090.0229) at 12\u2009months, respectively. There was one prolonged case of dysarthria at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show that MRgFUS Vo\u2010thalamotomy significantly improved FHD. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28613","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T05:32:45Z","timestamp":1622784765000},"page":"1955-1959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Magnetic Resonance\u2010Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study"],"prefix":"10.1002","volume":"36","author":[{"given":"Shiro","family":"Horisawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology Shinyurigaoka General Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Radiology Shinyurigaoka General Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatake","family":"Sumi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hodotsuka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Techno\u2010Surgery Institute of Advanced Biomedical Engineering &amp; Science, Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakazu","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute, Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8373-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13133"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10480"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070094"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199298723.003.0017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/175899830601100301"},{"issue":"3","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/aian.AIAN_15_17","article-title":"Surgical interventions for task\u2010specific dystonia (writer's dystonia)","volume":"20","author":"Doshi PK","year":"2017","journal-title":"Ann Indian Acad Neurol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1173"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30403-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.JNS173125"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004268"},{"key":"e_1_2_8_14_1","unstructured":"Fahn SJQond.Assessment of the primary dystonias.1989:241\u2013270."},{"key":"e_1_2_8_15_1","volume-title":"Georg Thieme","author":"Schaltenbrand G","year":"1977"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS16758"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27180"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13379"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26726"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23877"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006818"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.09.040"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/11\/0977"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:41:35Z","timestamp":1760960495000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/mds.28613"],"URL":"https:\/\/doi.org\/10.1002\/mds.28613","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}