{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:13:36Z","timestamp":1790954016530,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R276\u20102018\u2010294"],"award-info":[{"award-number":["R276\u20102018\u2010294"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with Parkinson's disease (PD) often develop dementia, but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo evidence is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to assess the density of synapses in non\u2010demented PD (nPD) subjects (N\u00a0=\u00a021), patients with PD\u2010dementia or Dementia with Lewy bodies (DLB) (N\u00a0=\u00a013), and age\u2010matched healthy controls (N\u00a0=\u00a015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Using in vivo PET imaging and the novel synaptic\u2010vesicle\u2010glycoprotein 2A (SV2A) radioligand [11C]UCB\u2010J, SUVR\u20101 values were obtained for 12 pre\u2010defined regions. Volumes\u2010of\u2010interest were defined on MRI T1 scans. Voxel\u2010level between\u2010group comparisons of [11C]UCB\u2010J SUVR\u20101 were performed. All subjects underwent neuropsychological assessment. Correlations between [11C]UCB\u2010 J PET and domain\u2010specific cognitive functioning were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>nPD patients only demonstrated significantly reduced SUVR\u20101 values in the substantia nigra (SN) compared to HC. DLB\/PDD patients demonstrated reduced SUVR\u20101 values in SN and all cortical VOIs except for the hippocampus and amygdala. The voxel\u2010based analysis supported the VOI results. Significant correlation was seen between middle frontal gyrus [11C]UCB\u2010J SUVR\u20101 and performance on tests of executive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Widespread cortical reduction of synaptic density was documented in a cohort of DLB\/PDD subjects using in vivo [11C]UCB\u2010J PET. Our study confirms previously reported synaptic loss in SN of nPD patients. [11C]UCB\u2010J binding in selected cortical VOIs of the DLB\/PDD patients correlated with their levels of cognitive function across relevant neuropsychological domains. These findings suggest that the loss of synaptic density contributes to cognitive impairment in nPD and DLB\/PDD. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28617","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T23:40:24Z","timestamp":1619394024000},"page":"2057-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Reduced Synaptic Density in Patients with Lewy Body Dementia: An [\n                    <scp>\n                      <sup>11<\/sup>\n                      C\n                    <\/scp>\n                    ]\n                    <scp>UCB\u2010J PET<\/scp>\n                    Imaging Study"],"prefix":"10.1002","volume":"36","author":[{"given":"Katrine B.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and PET Aarhus University 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