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Beta\u2010amyloid status was determined by cerebral \u03b2\u2010amyloid PET and\/or CSF analysis. Subcortical and cortical [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 binding was quantitatively and visually compared between \u03b2\u2010amyloid\u2010positive and \u2010negative patients and controls. Regional [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 binding was correlated with clinical and demographic data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four percent (11 of 45) were \u03b2\u2010amyloid\u2010positive. Significantly elevated [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 distribution volume ratios were observed in both \u03b2\u2010amyloid\u2010positive and \u03b2\u2010amyloid\u2010negative patients versus controls in the dorsolateral prefrontal cortex and basal ganglia. Cortical [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 PET positivity was distinctly higher in \u03b2\u2010amyloid\u2010positive compared with \u03b2\u2010amyloid\u2010negative patients with pronounced involvement of the dorsolateral prefrontal cortex. Semiquantitative analysis of [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 PET revealed a sensitivity of 91% for \u03b2\u2010amyloid\u2010positive and of 65% for \u03b2\u2010amyloid\u2010negative cases, which is in excellent agreement with prior clinicopathological data. Regardless of \u03b2\u2010amyloid status, hemispheric lateralization of [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 signal reflected contralateral predominance of clinical disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data indicate a value of [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 for evaluating corticobasal syndrome, providing quantitatively and regionally distinct signals in \u03b2\u2010amyloid\u2010positive as well as \u03b2\u2010amyloid\u2010negative corticobasal syndrome. In corticobasal syndrome, [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 may potentially serve for a differential diagnosis and for monitoring disease progression. \u00a9 2021 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28624","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T05:24:59Z","timestamp":1620278699000},"page":"2104-2115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Cortical [\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>PI<\/scp>\n                    \u20102620 Binding Differentiates Corticobasal Syndrome Subtypes"],"prefix":"10.1002","volume":"36","author":[{"given":"Carla","family":"Palleis","sequence":"first","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians\u2010University  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ludwig\u2010Maximilians\u2010University  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Finze","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ludwig\u2010Maximilians\u2010University  Munich 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