{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:30:19Z","timestamp":1790890219355,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005930","name":"ASCRS Research Foundation","doi-asserted-by":"publisher","award":["SCHN1265\/1\u20101"],"award-info":[{"award-number":["SCHN1265\/1\u20101"]}],"id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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Plasma samples were obtained from 2 independent cohorts. The T\u00fcbingen cohort contained 96 patients with PD, 50 patients with dementia with Lewy bodies, 50 patients with progressive supranuclear palsy (PSP), and 42 healthy controls; the Kassel cohort included 47 patients with PD, 43 patients with dementia with Lewy bodies, and 36 controls with secondary parkinsonian syndromes. Extracellular vesicles were prepared from total plasma by size exclusion chromatography and quantified by nanoparticle tracking analysis, \u03b1\u2010synuclein content was measured by an electrochemiluminescence assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u03b1\u2010Synuclein concentration in plasma extracellular vesicles provided the best discrimination between PD, dementia with Lewy bodies, PSP, and healthy controls, with an area under the curve of 0.804 (PD vs dementia with Lewy bodies), 0.815 (PD vs. PSP), and 0.769 (PD vs healthy controls) in the T\u00fcbingen cohort. Results were validated in the Kassel cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The concentration of \u03b1\u2010synuclein in plasma extracellular vesicles may serve as a potential diagnostic biomarker for PD. \u00a9 2021 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28639","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T08:17:31Z","timestamp":1621325851000},"page":"2508-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["<scp>\u03b1\u2010Synuclein<\/scp>\n                    in Plasma\u2010Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Anne","family":"Stuendl","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases DZNE  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Kraus","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases DZNE  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases DZNE  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Zapke","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases DZNE  Bonn 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