{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:49:38Z","timestamp":1786632578128,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2018_EKES.04"],"award-info":[{"award-number":["2018_EKES.04"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment with sphingosine\u20101\u2010phosphate (S1P) agonists confers neuroprotective effects in animal models of Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the association of serum S1P levels with motor and cognitive symptoms in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>S1P concentrations were analyzed with liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) in serum of 196 PD patients and in 196 age\u2010 and sex\u2010matched controls. Motor (Unified Parkinson's disease rating scale III [UPDRS III], Hoehn and Yahr) and cognitive (Montreal Cognitive Assessment [MoCA]) function were assessed at baseline. Follow\u2010up data was available from 64 patients (median [interquartile range], 513 [381\u2013677] days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      S1P levels were lower in PD patients compared with controls, that is 1.75 (1.38\u20132.07) and 1.90 (1.59\u20132.18) \u03bcmol\/L, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). In PD patients, lower S1P concentrations were associated with higher UPDRS III scores and Hoehn and Yahr stage. In the follow\u2010up cohort, S1P concentrations below the median were associated with faster motor decline (hazard ratio: 4.78 [95% CI, 1.98, 11.50]), but not with cognitive worsening.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our observations reveal an association of S1P with PD. \u00a9 2021 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28652","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T07:39:06Z","timestamp":1621409946000},"page":"2178-2182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sphingosine\u20101\u2010Phosphate, Motor Severity, and Progression in Parkinson's Disease (\n                    <scp>MARK\u2010PD<\/scp>\n                    )"],"prefix":"10.1002","volume":"36","author":[{"given":"Edzard","family":"Schwedhelm","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/ Luebeck  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrin","family":"Englisch","sequence":"additional","affiliation":[{"name":"Department of Neurology 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Marmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"B\u00f6ger","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/ Luebeck  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Peine","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine, University Medical Center Hamburg\u2010Eppendorf  Hamburg 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