{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:49:31Z","timestamp":1786632571841,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The landscape of genetic forms of Parkinson's diseases (PD) has grown exponentially in recent years. Today, around 10% of PD cases are estimated to be of genetic etiology. However, the link between parkinsonism or tremor and chromosome disorders, both numerical and structural, has been neglected. We reviewed the occurrence and characteristics of parkinsonism and tremor syndromes in patients with chromosomic disorders. We searched PubMed for articles published until December 2018, using the non\u2010MESH terms \u201cChromosomopathy,\u201d \u201ckaryotype,\u201d \u201cchromosome,\u201d \u201caneuploidy,\u201d \u201cdeletion,\u201d \u201cinversion,\u201d \u201cinsertion,\u201d \u201cduplication,\u201d and\n                    <jats:italic>\u201c<\/jats:italic>\n                    Parkinson,\u201d \u201cParkinsonism,\u201d \u201cTremor,\u201d and \u201cParkinsonian disorder.\u201d We restricted the search to human studies and selected articles for further analysis after abstract review. Tremor syndromes in which patients had another possible clinical reason for syndromes were excluded, as well as tremor syndromes associated with point mutations, imprinting syndromes, and patients presenting with other hyperkinetic disorders. Fifty\u2010four articles were reviewed. Aneuploidies of sex chromosomes were the most common chromosomopathy. These patients more commonly exhibited postural and kinetic tremor, often meeting the description of essential tremor. In structural chromosomopathies, the most frequent association was PD and 22q11.2 deletion syndrome, but we found case reports and case series of several additional deletion and duplication syndromes. \u00a9 2021 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.28663","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T05:07:02Z","timestamp":1622437622000},"page":"2017-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tremor and Parkinsonism in Chromosomopathies \u2014 A Systematic Review"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-0901","authenticated-orcid":false,"given":"Vanessa","family":"Carvalho","sequence":"first","affiliation":[{"name":"Neurology Department Hospital Pedro Hispano\/Unidade Local de Sa\u00fade de Matosinhos  Matosinhos 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