{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:00Z","timestamp":1790790300584,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solriamfetol is approved (US and EU) for excessive daytime sleepiness (EDS) in narcolepsy and obstructive sleep apnea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate solriamfetol safety\/efficacy for EDS in Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phase 2, double\u2010blind, 4\u2010week, crossover trial: adults with PD and EDS were randomized to sequence A (placebo, solriamfetol 75, 150, 300\u2009mg\/d), B (solriamfetol 75, 150, 300\u2009mg\/d, placebo), or C (placebo). Outcomes (safety\/tolerability [primary]; Epworth Sleepiness Scale [ESS]; Maintenance of Wakefulness Test [MWT]) were assessed weekly. <jats:italic>P<\/jats:italic> values are nominal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Common adverse events (n\u00a0=\u00a066): nausea (10.7%), dizziness (7.1%), dry mouth (7.1%), headache (7.1%), anxiety (5.4%), constipation (5.4%), dyspepsia (5.4%). ESS decreased both placebo (\u22124.78) and solriamfetol (\u22124.82 to \u22125.72; <jats:italic>P\u2009&gt;<\/jats:italic>\u00a00.05). MWT improved dose\u2010dependently with solriamfetol, increasing by 5.05\u2009minutes with 300\u2009mg relative to placebo (<jats:italic>P\u2009=<\/jats:italic>\u00a00.0098).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Safety\/tolerability was consistent with solriamfetol's known profile. There were no significant improvements on ESS; MWT results suggest possible benefit with solriamfetol in PD. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28702","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:09:58Z","timestamp":1625108998000},"page":"2408-2412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof\u2010of\u2010Concept Trial"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-1516","authenticated-orcid":false,"given":"Aleksandar","family":"Videnovic","sequence":"first","affiliation":[{"name":"Movement Disorders Unit and Division of Sleep Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy W.","family":"Amara","sequence":"additional","affiliation":[{"name":"Division of Movement Disorders, Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Comella","sequence":"additional","affiliation":[{"name":"Parkinson's Disease and Movement Disorders Program Rush University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula K.","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Sleep Medicine and Research Center St. Luke's Hospital  Chesterfield Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Emsellem","sequence":"additional","affiliation":[{"name":"The Center for Sleep &amp; Wake Disorders  Chevy Chase Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Liu","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Sterkel","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mildred D.","family":"Gottwald","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Steinerman","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Jochelson","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Zomorodi","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-1203","authenticated-orcid":false,"given":"Robert A.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Parkinson's Disease and Movement Disorders Center University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.08.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0775"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539720-000000000-00000"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0838-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276402"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20412"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23462"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.05.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55f24"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.065870"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.8.62"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.03.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.248120"},{"key":"e_1_2_9_16_1","unstructured":"Sunosi\u2122 (solriamfetol) Tablets.Prescribing Information. 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