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Diagnostic groups were compared using the Kruskal\u2212Wallis rank test. Within PD, cross\u2010sectional associations between NfL and Unified Parkinson's Disease Rating Scale Part III (UPDRS\u2010III) and Mattis Dementia Rating Scale (DRS\u20102) scores were assessed by linear regression; longitudinal analyses were performed using linear mixed\u2010effects models and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma and CSF NfL levels correlated substantially (Spearman r\u00a0=\u00a00.64, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); NfL was highest in neurocognitive disorders. PD participants with high plasma NfL were more likely to develop incident cognitive impairment (HR 5.34, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma NfL is a useful prognostic biomarker for PD, predicting clinical conversion to mild cognitive impairment or dementia. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28779","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T03:54:00Z","timestamp":1630727640000},"page":"2945-2950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-2809","authenticated-orcid":false,"given":"Whitley W.","family":"Aamodt","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Waligorska","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurodegenerative Disease Research Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-1496","authenticated-orcid":false,"given":"Thomas F.","family":"Tropea","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurodegenerative Disease Research Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Siderowf","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurodegenerative Disease Research Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease Research Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Parkinson's Disease and Mental Illness Research, Education, and Clinical Centers Philadelphia Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurodegenerative Disease Research Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-5098","authenticated-orcid":false,"given":"David","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of 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