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variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a meta\u2010analysis using imputed genotypes from 17,838 patients, 13,404 proxy patients, and 173,639 healthy controls of European ancestry. We excluded carriers of p.G2019S and\/or rs76904798 to clarify the role of <jats:italic>LRRK2<\/jats:italic> coding variation in mediating disease risk and excluded carriers of relatively rare <jats:italic>LRRK2<\/jats:italic> coding variants to assess the independence of rs76904798. We also investigated the co\u2010inheritance of <jats:italic>LRRK2<\/jats:italic> coding variants with p.G2019S, rs76904798, and p.N2081D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>LRRK2<\/jats:italic> rs76904798 remained significantly associated with PD after excluding the carriers of relatively rare <jats:italic>LRRK2<\/jats:italic> coding variants. <jats:italic>LRRK2<\/jats:italic> p.R1514Q and p.N2081D were frequently co\u2010inherited with rs76904798, and the allele distribution of p.S1647T significantly changed among patients after removing rs76904798 carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that the <jats:italic>LRRK2<\/jats:italic> coding variants previously related to PD (p.N551K, p.R1398H, p.M1646T, and p.N2081D) do not drive the 5\u2032 noncoding GWAS signal. These data, however, do not preclude the independent association of the haplotype p.N551K\u2010p.R1398H and p.M1646T with altered disease risk. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28787","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T11:56:25Z","timestamp":1632138985000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Coding and Noncoding Variation in <scp><i>LRRK2<\/i><\/scp> and Parkinson's Disease Risk"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3441-2455","authenticated-orcid":false,"given":"Julie","family":"Lake","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xylena","family":"Reed","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National 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