{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:28:24Z","timestamp":1787801304906,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanopsin retinal ganglion cell (mRGC)\u2010mediated pupillary light reflex (PLR) abnormalities have been documented in several neurodegenerative disorders including Parkinson's disease. Overall, isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents the strongest prodromal risk factor for impending \u03b1\u2010synucleinopathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To quantitatively compare PLR and mRGC\u2010mediated contribution to PLR in 16 iRBD patients and 16 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>iRBD and controls underwent extensive neuro\u2010ophthalmological evaluation and chromatic pupillometry. In iRBD, PLR metrics were correlated with clinical variables and with additional biomarkers including REM atonia index (RAI), DaTscan, and presence of phosphorylated\u2010\u03b1\u2010synuclein (p\u2010\u03b1\u2010syn) deposition in skin biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We documented higher baseline pupil diameter and decreased rod\u2010transient PLR amplitude in iRBD patients compared to controls. PLR rod\u2010contribution correlated with RAI. Moreover, only iRBD patients with evidence of p\u2010\u03b1\u2010syn deposition at skin biopsy showed reduced PLR amplitude compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The observed PLR abnormalities in iRBD might be considered as potential biomarkers for the risk stratification of phenoconversion of the disease. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28809","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T10:49:55Z","timestamp":1633776595000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-8929","authenticated-orcid":false,"given":"Chiara","family":"La Morgia","sequence":"first","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-558X","authenticated-orcid":false,"given":"Martina","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"},{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Biscarini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-8314","authenticated-orcid":false,"given":"Marco","family":"Filardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"},{"name":"Department of Basic Medicine, Neuroscience, and Sense Organs University of Bari \"Aldo Moro\"  Bari Italy"},{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \"Aldo Moro\"\u2010 A.O. Pia Fondazione Cardinale G. Panico  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-7318","authenticated-orcid":false,"given":"Vincenzo","family":"Donadio","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carbonelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Amore","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Biomedicina e Movimento Universit\u00e0 di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Carelli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"},{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Liguori","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"},{"name":"Dipartimento di Scienze Biomediche e Neuromotorie Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica  Bologna Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-6139","authenticated-orcid":false,"given":"Elena","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Biomedicina e Movimento Universit\u00e0 di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03641-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24181"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00780"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26078-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0596-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28585"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50833"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-01956-z"},{"key":"e_1_2_9_11_1","volume-title":"International Classification of Sleep Disorders. 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