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Increased [<jats:sup>18<\/jats:sup>F]\u2010FEMPA binding in the dentate nuclei, brainstem, and cerebellar anterior lobe correlated with earlier age of symptom onset (controlling for the genetic triplet repeat expansion length; all <jats:italic>r<\/jats:italic><jats:sub>\n<jats:italic>part<\/jats:italic><\/jats:sub>\u2009&lt;\u2009\u22120.6), and in the pons and anterior lobe with shorter disease duration (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.66; \u22120.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuroinflammation is evident in brain regions implicated in FRDA neuropathology. Increased neuroimmune activity may be related to earlier disease onset and attenuate over the course of the illness. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28825","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T21:55:46Z","timestamp":1634421346000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Neuroinflammation in the Cerebellum and Brainstem in Friedreich Ataxia: An [<scp><sup>18<\/sup>F<\/scp>]\u2010<scp>FEMPA PET<\/scp> Study"],"prefix":"10.1002","volume":"37","author":[{"given":"Wasim","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise 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