{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:50:27Z","timestamp":1783475427834,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Huntington's disease is a neurodegenerative disorder characterized by clinical alterations in the motor, behavioral, and cognitive domains. However, the structure and disruptions to large\u2010scale brain cognitive networks have not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to profile changes in large\u2010scale cognitive networks in premanifest and symptomatic patients with Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively recruited premanifest and symptomatic Huntington's disease mutation carriers as well as healthy controls. Clinical and sociodemographic data were obtained from all participants, and resting\u2010state functional connectivity data, using both time\u2010averaged and dynamic functional connectivity, was acquired from whole\u2010brain and cognitively oriented brain parcellations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 gene mutation carriers and 23 healthy controls were included; 21 patients with Huntington's disease were classified as premanifest and 43 as symptomatic Huntington's disease. Compared with healthy controls, patients with Huntington's disease showed decreased network connectivity within the posterior hubs of the default\u2010mode network and the medial prefrontal cortex, changes that correlated with cognitive (<jats:italic>t<\/jats:italic>\u00a0=\u00a02.25, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and disease burden scores (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u22122.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). The salience network showed decreased functional connectivity between insular and supramarginal cortices and also correlated with cognitive (<jats:italic>t<\/jats:italic>\u00a0=\u00a02.11, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and disease burden scores (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u22122.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Dynamic analyses showed that network variability was decreased for default\u2010central executive networks, a feature already present in premanifest mutation carriers (dynamic factor 8, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Huntington's disease shows an early and widespread disruption of large\u2010scale cognitive networks. Importantly, these changes are related to cognitive and disease burden scores, and novel dynamic functional analyses uncovered subtler network changes even in the premanifest stages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28839","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T05:45:54Z","timestamp":1636436754000},"page":"343-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Structure and Dynamics of Large\u2010Scale Cognitive Networks in Huntington's Disease"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-5025","authenticated-orcid":false,"given":"Ignacio","family":"Aracil\u2010Bola\u00f1os","sequence":"first","affiliation":[{"name":"Movement Disorders Unit, Neurology Department Sant Pau Hospital  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Institut 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