{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:38:45Z","timestamp":1790293125789,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel combination drug of modafinil and low\u2010dose flecainide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to evaluate the safety and efficacy of THN102 in PD patients with EDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The method involved a randomized, double\u2010blind, placebo\u2010controlled, crossover trial testing two doses of THN102 (200\u2009mg\/d modafinil with 2\u2009mg\/d [200\/2] or 18\u2009mg\/d flecainide [200\/18]) versus placebo; 75 patients were exposed to treatment. The primary endpoint was safety. The primary efficacy outcome was the change in Epworth Sleepiness Scale (ESS) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both doses of THN102 were well tolerated. ESS significantly improved with THN102 200\/2 (least square means vs. placebo [95% confidence interval, CI]: \u22121.4 [\u22122.49; \u22120.31], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012) but did not change significantly with the 200\/18 dosage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>THN102 was well tolerated and showed a signal of efficacy at the 200\/2 dose, supporting further development for the treatment of EDS in PD. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28840","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T08:45:47Z","timestamp":1635410747000},"page":"410-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>THN<\/scp> 102 for Excessive Daytime Sleepiness Associated with Parkinson's Disease: A Phase 2a Trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7325-0199","authenticated-orcid":false,"given":"Jean\u2010Christophe","family":"Corvol","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre d'Investigation Clinique Neurosciences, NS\u2010PARK\/FCRIN Network Sorbonne Universit\u00e9, Assistance Publique H\u00f4pitaux de Paris, Paris Brain Institute\u2014ICM, INSERM, CNRS, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Azulay","sequence":"additional","affiliation":[{"name":"Department of Neurology and Movement Disorders La Timone Hospital, Assistance Publique\u2010H\u00f4pitaux de Marseille, NS\u2010PARK\/FCRIN Network  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Bosse","sequence":"additional","affiliation":[{"name":"Scope International  Mannheim 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School University of Pecs  Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malt\u00eate","sequence":"additional","affiliation":[{"name":"Department of Neurology Rouen University Hospital and University of Rouen, NS\u2010PARK\/FCRIN Network  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Ondo","sequence":"additional","affiliation":[{"name":"Movement Disorders\u2010Methodist Neurological Institute Weill Cornel Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Pahwa","sequence":"additional","affiliation":[{"name":"Movement Disorders Division University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Rein","sequence":"additional","affiliation":[{"name":"Theranexus SA  Lyon 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