{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:30:51Z","timestamp":1790937051833,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent examination of the STEADY\u2010PD III isradipine clinical trial data concluded that early\u2010stage Parkinson's disease (PD) participants who had longer exposure to isradipine had a significant delay in their need for symptomatic medication, as well as a lower medication burden at the end of the trial. These findings suggest that greater exposure to isradipine might slow disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test this hypothesis, the data from the STEADY\u2010PD II isradipine clinical trial, in which an extended\u2010release (ER) formulation of the drug was used, was re\u2010examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The re\u2010analysis of the STEADY\u2010PD II data was restricted to participants assigned placebo or tolerable isradipine treatment (10\u2009mg isradipine\/day or less). The effect of isradipine treatment was assessed by Unified Parkinson's Disease Rating Scale (UPDRS) at the end of the 52\u2010week trial, rather than by last observation carried forward at the beginning of symptomatic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participant cohorts were well\u2010matched for baseline disability, initial disease progression, and time to initiation of symptomatic therapy. Participants given 10\u2009mg\/day ER isradipine had significantly smaller total and part 3 UPDRS scores at the end of the trial than did the placebo cohort. Post hoc adjustment for symptomatic therapy diminished the statistical significance of these differences. In those participants not taking a monoamine oxidase B inhibitor, the progression in UPDRS scores also was significantly reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results are consistent with the recent secondary analysis of the STEADY\u2010PD III clinical trial\u2014suggesting that clinically attainable brain exposure to isradipine may slow early\u2010stage PD progression. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28850","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T06:50:10Z","timestamp":1636699810000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Re\u2010Analysis of the <scp>STEADY\u2010PD II<\/scp> Trial\u2014Evidence for Slowing the Progression of Parkinson's Disease"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-5225","authenticated-orcid":false,"given":"D. James","family":"Surmeier","sequence":"first","affiliation":[{"name":"Department of Neuroscience Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Cavalon Therapeutics  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Lancki","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Center Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Venuto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Health and Technology University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Department of Neurology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Wyse","sequence":"additional","affiliation":[{"name":"Cure Parkinsons  London United 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