{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:43:50Z","timestamp":1775497430244,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015998","name":"ParkinsonFonds Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015998","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008383","name":"Stichting ParkinsonFonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for \u03b1\u2010synucleinopathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine whether pathological cardiac [<jats:sup>123<\/jats:sup>I]meta\u2010iodobenzylguanidine scintigraphy ([<jats:sup>123<\/jats:sup>I]MIBG) is associated with progression of [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose\u2010positron emission tomography\u2013based Parkinson's disease (PD)\u2010related brain pattern (PDRP) expression in iRBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen subjects with iRBD underwent [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose\u2010positron emission tomography brain imaging twice ~3.6\u2009years apart. In addition, [<jats:sup>123<\/jats:sup>I]MIBG and [<jats:sup>123<\/jats:sup>I]<jats:italic>N<\/jats:italic>\u2010\u03c9\u2010fluoropropyl\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)nortropane single\u2010photon emission computed tomography ([<jats:sup>123<\/jats:sup>I]FP\u2010CIT\u2010SPECT) at baseline were performed. Olfactory, cognitive, and motor functions were tested annually.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve of 17 subjects had pathological [<jats:sup>123<\/jats:sup>I]MIBG. At baseline, 6 of 12 of these expressed the PDRP (suprathreshold PDRP <jats:italic>z<\/jats:italic> score). At follow\u2010up, 12 of 17 subjects had suprathreshold PDRP <jats:italic>z<\/jats:italic> scores, associated with pathological [<jats:sup>123<\/jats:sup>I]MIBG in 92% and with pathological [<jats:sup>123<\/jats:sup>I]FP\u2010CIT\u2010SPECT in 75%. Subjects with pathological [<jats:sup>123<\/jats:sup>I]MIBG had higher PDRP <jats:italic>z<\/jats:italic> score change per year (<jats:italic>P\u2009=<\/jats:italic>\u00a00.027). Three subjects phenoconverted to PD; all had pathological [<jats:sup>123<\/jats:sup>I]MIBG and [<jats:sup>123<\/jats:sup>I]FP\u2010CIT\u2010SPECT, suprathreshold baseline PDRP <jats:italic>z<\/jats:italic> scores, and hyposmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pathological [<jats:sup>123<\/jats:sup>I]MIBG was associated with progressive and suprathreshold PDRP <jats:italic>z<\/jats:italic> scores at follow\u2010up. Abnormal [<jats:sup>123<\/jats:sup>I]MIBG likely identifies iRBD as prodromal PD earlier than pathological [<jats:sup>123<\/jats:sup>I]FP\u2010CIT\u2010SPECT. \u00a9 2021 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28859","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T05:07:03Z","timestamp":1637298423000},"page":"624-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>Rapid Eye Movement<\/scp> Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-5831","authenticated-orcid":false,"given":"Annette","family":"Janzen","sequence":"first","affiliation":[{"name":"Department of Neurology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-4181","authenticated-orcid":false,"given":"Rosalie V.","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne K.","family":"Meles","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Sittig","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remco J.","family":"Renken","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells &amp; Systems University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanni F.","family":"Geibl","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC, Academic Medical Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Stormezand","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Luster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus L.","family":"Leenders","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Neurology University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University Marburg  Marburg Germany"},{"name":"Institute for Neurogenomics, Helmholtz Center for Health and Environment  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089741"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.09.013"},{"issue":"1","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/brain\/awh322","article-title":"Combination of \u2018idiopathic\u2019 REM sleep behaviour disorder and olfactory dysfunction as possible indicator for 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