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The ability to visualize and longitudinally monitor tau deposits may be beneficial to understand disease pathophysiology and predict clinical trajectories.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of this study was to investigate the cross\u2010sectional and longitudinal 18<\/jats:sup>F\u2010APN\u20101607 positron emission tomography\/computed tomography (PET\/CT) imaging findings in MAPT<\/jats:italic> mutation carriers.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seven carriers of MAPT<\/jats:italic> mutations (six within exon 10 and one outside of exon 10) and 15 healthy control subjects were included. All participants underwent 18<\/jats:sup>F\u2010APN\u20101607 PET\/CT at baseline. Three carriers of exon 10 mutations received follow\u2010up 18<\/jats:sup>F\u2010APN\u20101607 PET\/CT scans. Standardized uptake value ratio (SUVR) maps were obtained using the cerebellar gray matter as the reference region. SUVR values observed in MAPT<\/jats:italic> mutation carriers were normalized to data from healthy control subjects. A regional SUVR z<\/jats:italic> score \u2265\u20092 was used as the criterion to define positive 18<\/jats:sup>F\u2010APN\u20101607 PET\/CT findings.<\/jats:p><\/jats:sec>Results<\/jats:title>Although the seven study patients had heterogenous clinical phenotypes, all showed a significant 18<\/jats:sup>F\u2010APN\u20101607 uptake characterized by high\u2010contrast signals. However, the anatomical localization of tau deposits differed in patients with distinct clinical symptoms. Follow\u2010up imaging data, which were available for three patients, demonstrated worsening trends in patterns of tau accumulation over time, which were paralleled by a significant clinical deterioration.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our data represent a promising step in understanding the usefulness of 18<\/jats:sup>F\u2010APN\u20101607 PET\/CT imaging for detecting tau accumulation in MAPT<\/jats:italic> mutation carriers. Our preliminary follow\u2010up data also suggest the potential value of 18<\/jats:sup>F\u2010APN\u20101607 PET\/CT for monitoring the longitudinal trajectories of frontotemporal lobar degeneration caused by MAPT<\/jats:italic> mutations. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28867","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T07:12:05Z","timestamp":1638169925000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["In Vivo<\/i>18<\/sup>F\u2010APN<\/scp>\u20101607 Tau Positron Emission Tomography<\/scp> Imaging in MAPT<\/i><\/scp> Mutations: Cross\u2010Sectional and Longitudinal Findings"],"prefix":"10.1002","volume":"37","author":[{"given":"Xin\u2010Yue","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"PET Center, Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"PET Center, Huashan Hospital Fudan University Shanghai 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