{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:41:00Z","timestamp":1791841260855,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ\u2010DRO\u2010VFN64165"],"award-info":[{"award-number":["MH CZ\u2010DRO\u2010VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU20\u201008\u201000445"],"award-info":[{"award-number":["NU20\u201008\u201000445"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015998","name":"ParkinsonFonds Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015998","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impairments of olfactory and speech function are likely early prodromal symptoms of \u03b1\u2010synucleinopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to assess whether dysprosody is present in isolated rapid eye movement sleep behavior disorder (iRBD) with hyposmia\/anosmia and a normal nigrostriatal system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pitch variability during speech was investigated in 17 iRBD subjects with normal olfactory function (iRBD\u2010NOF), 30 iRBD subjects with abnormal olfactory function (iRBD\u2010AOF), and 50 healthy controls. iRBD subjects were evaluated using the University of Pennsylvania Smell Identification Test and [123I]\u20102\u00df\u2010carbomethoxy\u20103\u00df\u2010(4\u2010iodophenyl)\u2010<jats:italic>N<\/jats:italic>\u2010(3\u2010fluoropropyl)\u2010nortropane dopamine transporter single\u2010photon emission computed tomography (DAT\u2010SPECT). All iRBD subjects completed the 24\u2010month follow\u2010up with DAT\u2010SPECT, speech, and olfactory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, only iRBD\u2010AOF showed monopitch when compared to iRBD\u2010NOF (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), with no difference between iRBD\u2010NOF and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a01). At follow\u2010up, dysprosody progressed only in iRBD\u2010AOF with abnormal DAT\u2010SPECT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prosody is impaired in hyposmic but not in normosmic iRBD subjects before the nigrostriatal dopaminergic transmission is affected (Braak stage 2). \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28873","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T02:36:23Z","timestamp":1637980583000},"page":"619-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dysprosody in Isolated <scp>REM<\/scp> Sleep Behavior Disorder with Impaired Olfaction but Intact Nigrostriatal Pathway"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-3054","authenticated-orcid":false,"given":"Jan","family":"Rusz","sequence":"first","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague  Prague Czech Republic"},{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-5831","authenticated-orcid":false,"given":"Annette","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Tykalov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zogala","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital  Prague Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-9661","authenticated-orcid":false,"given":"Ev\u017een","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"\u0160onka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-9642","authenticated-orcid":false,"given":"Petr","family":"Du\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Oertel","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00176-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2018.2851787"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26085"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx071"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz111"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51710-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_9_10_1","volume-title":"International Classification of Sleep Disorders, Third Edition: Diagnostic and Coding Manual","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20153"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1267-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0357-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28465"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2945874"},{"key":"e_1_2_9_19_1","unstructured":"HlavnickaJ.Automated analysis of speech disorders in neurodegenerative diseases. PhD Thesis Faculty of Electrical Engineering Czech Technical University Prague Czechia2018."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi061"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(96)80016-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.6.2500"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012878"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa238"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28873","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:32:38Z","timestamp":1760970758000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/mds.28873"],"URL":"https:\/\/doi.org\/10.1002\/mds.28873","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}