{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:46Z","timestamp":1790938066662,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF Research grant 2012"],"award-info":[{"award-number":["MJFF Research grant 2012"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The \u201cdual syndrome hypothesis\u201d distinguished two subtypes in mild cognitive impairment (MCI) in Parkinson's disease: frontostriatal, characterized by attentional and executive deficits; and posterior cortical, characterized by visuospatial, memory, and language deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to identify resting\u2010state functional modifications associated with these subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010five nondemented patients categorized as having normal cognition (n\u00a0=\u00a031), frontostriatal (n\u00a0=\u00a014), posterior cortical (n\u00a0=\u00a020), or mixed (n\u00a0=\u00a030) cognitive subtype had a 3\u2009T resting\u2010state functional magnetic resonance imaging scan. Twenty\u2010four age\u2010matched healthy controls (HCs) were also included. A group\u2010level independent component analysis was performed to identify resting\u2010state networks, and the selected components were subdivided into 564 cortical regions in addition to 26 basal ganglia regions. Global intra\u2010 and inter\u2010network connectivity along with global and local efficiencies was compared between groups. The network\u2010based statistics approach was used to identify connections significantly different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with posterior cortical deficits had increased intra\u2010network functional connectivity (FC) within the basal ganglia network compared with patients with frontostriatal deficits. Patients with frontostriatal deficits had reduced inter\u2010network FC between several networks, including the visual, default\u2010mode, sensorimotor, salience, dorsal attentional, basal ganglia, and frontoparietal networks, compared with HCs, patients with normal cognition, and patients with a posterior cortical subtype. Similar results were also found between patients with a mixed subtype and HCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCI subtypes are associated with specific changes in resting\u2010state FC. Longitudinal studies are needed to determine the predictive potential of these markers regarding the risk of developing dementia. \u00a9 2021 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28888","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T08:26:14Z","timestamp":1639729574000},"page":"502-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Resting\u2010State Functional Connectivity in Frontostriatal and Posterior Cortical Subtypes in Parkinson's Disease\u2010Mild Cognitive Impairment"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7544-6328","authenticated-orcid":false,"given":"Quentin","family":"Devignes","sequence":"first","affiliation":[{"name":"Univ. 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