{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:08:54Z","timestamp":1792649334167,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016242","name":"Boston Scientific Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with dyskinetic cerebral palsy are often severely impaired with limited treatment options. The effects of deep brain stimulation (DBS) are less pronounced than those in inherited dystonia but can be associated with favorable quality of life outcomes even in patients without changes in dystonia severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim is to assess DBS effects in pediatric patients with pharmacorefractory dyskinetic cerebral palsy with focus on quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The method used is a prospective, single\u2010arm, multicenter study. The primary endpoint is improvement in quality of life (CPCHILD [Caregiver Priorities &amp; Child Health Index of Life with Disabilities]) from baseline to 12\u00a0months under therapeutic stimulation. The main key secondary outcomes are changes in Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale, Dyskinesia Impairment Scale, Gross Motor Function Measure\u201066, Canadian Occupational Performance Measure (COPM), and Short\u2010Form (SF)\u201036. After 12\u00a0months, patients were randomly assigned to a blinded crossover to receive active or sham stimulation for 24\u2009hours each. Severity of dystonia and chorea were blindly rated. Safety was assessed throughout. The trial was registered at ClinicalTrials.gov, number NCT02097693.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen patients (age: 13.4\u2009\u00b1\u20092.9\u2009years) were recruited by seven clinical sites. Primary outcome at 12\u2010month follow\u2010up is as follows: mean CPCHILD increased by 4.2\u2009\u00b1\u200910.4 points (95% CI [confidence interval] \u20131.3 to 9.7;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.125); among secondary outcomes: improvement in COPM performance measure of 1.1\u2009\u00b1\u20091.5 points (95% CI 0.2 to 1.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02) and in the SF\u201036 physical health component by 5.1\u2009\u00b1\u20096.2 points (95% CI 0.7 to 9.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.028). Otherwise, there are no significant changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Evidence to recommend DBS as routine treatment to improve quality of life in pediatric patients with dyskinetic cerebral palsy is not yet sufficient. Extended follow\u2010up in larger cohorts will determine the impact of DBS further to guide treatment decisions in these often severely disabled patients. \u00a9 2021 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28898","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T02:33:56Z","timestamp":1640831636000},"page":"799-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single\u2010Arm, Multicenter Study with a Subsequent Randomized Double\u2010Blind Crossover (\n                    <scp>STIM\u2010CP<\/scp>\n                    )"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-4432","authenticated-orcid":false,"given":"Anne","family":"Koy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Huebl","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 University Medicine Berlin  Berlin Germany"},{"name":"Department of Neurology Munich Municipal Hospital Bogenhausen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd\u2010Helge","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Charit\u00e9 University Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"van Riesen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Eckenweiler","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics and Muscle Disorders University Medical Center, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Rensing\u2010Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics and Muscle Disorders University Medical Center, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker Arnd","family":"Coenen","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery University Medical Center, Faculty of Medicine, University of Freiburg  Freiburg Germany"},{"name":"Department of Stereotactic and Functional Neurosurgery Center for Deep Brain Stimulation, University Medical Center  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-9064","authenticated-orcid":false,"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Saryyeva","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover 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