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population\u2010based cohorts of newly diagnosed PD patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>1002 PD<\/jats:styled-content> patients, followed for up to 10\u2009years (median 7.2\u2009years), were genotyped for at least one of APOE<\/jats:italic><\/jats:styled-content>\u2010\u03b54, GBA<\/jats:italic><\/jats:styled-content> mutations, MAPT<\/jats:italic> H1<\/jats:styled-content>\/H2<\/jats:styled-content>, or SNCA<\/jats:italic><\/jats:styled-content> rs356219. We evaluated the effect of genotype on the rate of cognitive decline (Mini\u2010Mental State Examanation, MMSE<\/jats:styled-content>) using linear mixed models and the development of dementia (diagnosed using standardized criteria) using Cox regression; multiple comparisons were accounted for using Benjamini\u2212Hochberg<\/jats:styled-content> corrections.<\/jats:p><\/jats:sec>Results<\/jats:title>Carriers of APOE<\/jats:italic>\u2010\u03b54 (n\u00a0=\u00a0281, 29.7%) and GBA<\/jats:italic> mutations (n\u00a0=\u00a0100, 10.3%) had faster cognitive decline and were at higher risk of progression to dementia (APOE<\/jats:italic>\u2010\u03b54, HR 3.57, P<\/jats:italic>\u2009<\u20090.001; GBA<\/jats:italic> mutations, HR 1.76, P<\/jats:italic>\u00a0=\u00a00.001) than non\u2010carriers. The risk of cognitive decline and dementia (HR 5.19, P<\/jats:italic>\u2009<\u20090.001) was further increased in carriers of both risk genotypes (n\u00a0=\u00a023). No significant effects were observed for MAPT<\/jats:italic> or SNCA<\/jats:italic> rs356219.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>GBA<\/jats:italic><\/jats:styled-content> and APOE<\/jats:italic><\/jats:styled-content> genotyping could improve the prediction of cognitive decline in PD<\/jats:styled-content>, which is important to inform the clinical trial selection and potentially to enable personalized treatment \u00a9 2022 The Authors. Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28932","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T04:05:35Z","timestamp":1643774735000},"page":"1016-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["GBA<\/i><\/scp> and APOE<\/i><\/scp> Impact Cognitive Decline in Parkinson's Disease: A 10\u2010Year Population\u2010Based Study"],"prefix":"10.1002","volume":"37","author":[{"given":"Aleksandra A.","family":"Szwedo","sequence":"first","affiliation":[{"name":"The Norwegian Center for Movement Disorders Stavanger University Hospital Stavanger Norway"},{"name":"Department of Chemistry, Bioscience and Environmental Engineering University of Stavanger Stavanger 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