{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:26:56Z","timestamp":1771306016159,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["Progres Q25"],"award-info":[{"award-number":["Progres Q25"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sialic acid\u2013protein interactions are involved in regulating central nervous system immunity; therefore, derangements in sialylation could be involved in neurodegeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluate the differences in serum transferrin sialylation in prodromal and early\u2010stage Parkinson's disease (PD), its relation to substantia nigra degeneration, and the risk of phenoconversion to manifest disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty treatment\u2010naive PD patients; 72 polysomnography\u2010confirmed isolated rapid eye movement sleep behavior disorder (iRBD) patients, that is, patients with prodromal synucleinopathy; and 46 healthy volunteers aged \u226545\u2009years and drinking \u226460 standard drinks per month were included. The proportion of serum low\u2010sialylated, carbohydrate\u2010deficient transferrin (CDT) isoforms was assessed using high\u2010performance liquid chromatography, and the values were adjusted for alcohol intake (CDT<jats:sub>adj<\/jats:sub>). Dopamine transporter single\u2010photon emission computed tomography (DaT\u2010SPECT) imaging was performed. In iRBD, phenoconversion risk of DaT\u2010SPECT and CDT<jats:sub>adj<\/jats:sub> was evaluated using Cox regression adjusted for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median CDT<jats:sub>adj<\/jats:sub> was lower in PD (1.1 [interquartile range: 1.0\u20131.3]%) compared to controls (1.2 [1.1\u20131.6]%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). In iRBD, median CDT<jats:sub>adj<\/jats:sub> was lower in subjects with abnormal (1.1 [0.9\u20131.3]%) than normal (1.3 [1.2\u20131.6]%) DaT\u2010SPECT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). After a median 44\u2010month follow\u2010up, 20% of iRBD patients progressed to a manifest disease. Although iRBD converters and nonconverters did not significantly differ in CDT<jats:sub>adj<\/jats:sub> levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.189), low CDT<jats:sub>adj<\/jats:sub> increased the risk of phenoconversion with hazard ratio 3.2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) but did not refine the phenoconversion risk associated with abnormal DaT\u2010SPECT yielding hazard ratio 15.8 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased serum CDT<jats:sub>adj<\/jats:sub> is associated with substantia nigra degeneration in synucleinopathies. iRBD patients with low CDT<jats:sub>adj<\/jats:sub> are more likely to phenoconvert to manifest disease. \u00a9 2022 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28942","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T03:34:41Z","timestamp":1644204881000},"page":"983-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Transferrin Sialylation Predicts Phenoconversion in Isolated <scp>REM<\/scp> Sleep Behavior Disorder"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-6299","authenticated-orcid":false,"given":"Ranjani","family":"Ganapathy S.","sequence":"first","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Levov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Kota\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Trnka","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zogala","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-3054","authenticated-orcid":false,"given":"Jan","family":"Rusz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"},{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Zima","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech 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