{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:53:59Z","timestamp":1786632839470,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The reliability of the Progressive Supranuclear Palsy Rating Scale (PSPRS) using teleneurology has not been assessed.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To test whether removing items inadequately assessed by video would impact measurement of PSP severity and progression.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed secondary analyses of two data sets: the phase 2\/3 trial of Davunetide in PSP and a large single\u2010center cohort. We examined two modifications of the PSPRS: (1) removing neck rigidity, limb rigidity, and postural stability (25 items; mPSPRS\u201025) and (2) also removing three ocular motor items and limb dystonia (21 items; mPSPRS\u201021). Proportional agreement relative to the possible total scores was measured using the intraclass correlation coefficient, compared to the original PSPRS baseline values and change over 6 and 12\u00a0months. We examined the ability of both scales to predict survival in the single\u2010center cohort using proportional hazards models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mPSPRS\u201025 showed excellent agreement (0.99;\n P<\/jats:italic>\n \u2009<\u20090.001) with the original PSPRS at baseline, 0.98 (\n P<\/jats:italic>\n \u2009<\u20090.001) agreement in measuring change over 6\u2009months, and 0.98 (\n P<\/jats:italic>\n \u2009<\u20090.001) over 12\u00a0months. The mPSPRS\u201021 showed agreement of 0.94 (\n P<\/jats:italic>\n \u2009<\u20090.001) with the original PSPRS at baseline, 0.92 (\n P<\/jats:italic>\n \u2009<\u20090.001) at 6\u2009months, and 0.95 (\n P<\/jats:italic>\n \u2009<\u20090.001) at 12\u00a0months. Baseline and 6\u2010month change in both modified scales were highly predictive of survival in the single\u2010center cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Modified versions of the PSPRS which can be administered remotely show excellent agreement with the original scale and predict survival in PSP. The mPSPRS\u201021 should facilitate clinical care and research in PSP via teleneurology. \u00a9 2022 International Parkinson and Movement Disorder Society<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.28991","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:44:46Z","timestamp":1648817086000},"page":"1265-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Modified Progressive Supranuclear Palsy Rating Scale for Virtual Assessments"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-4711","authenticated-orcid":false,"given":"Anne\u2010Marie","family":"Wills","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pantelyat","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-136X","authenticated-orcid":false,"given":"Alberto","family":"Espay","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chan","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-3445","authenticated-orcid":false,"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[{"name":"Parkinson and Other Movement Disorders Center, UC San Diego, Department of Neurosciences La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-6613","authenticated-orcid":false,"given":"Tao","family":"Xie","sequence":"additional","affiliation":[{"name":"Movement Disorder Program, Department of Neurology University of Chicago Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-982X","authenticated-orcid":false,"given":"Marian L.","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health & Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-9022","authenticated-orcid":false,"given":"Steven A.","family":"Gunzler","sequence":"additional","affiliation":[{"name":"Parkinson's and Movement Disorders Center, Neurological Institute University Hospitals Cleveland Medical Center and Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8497","authenticated-orcid":false,"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, Rossy Progressive Supranuclear Palsy Centre, University of Toronto, Krembil Brain Institute University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Fox","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease, Rossy Progressive Supranuclear Palsy Centre, Movement Disorders Clinic, Krembil Brain Institute, Toronto Western Hospital, University Health Network and Division of Neurology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-5095","authenticated-orcid":false,"given":"Federico","family":"Rodriguez\u2010Porcel","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease, Rossy Progressive Supranuclear Palsy Centre, Movement Disorders Clinic, Krembil Brain Institute, Toronto Western Hospital, University Health Network and Division of Neurology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AL\u2010108\u2010231 Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-3365","authenticated-orcid":false,"given":"Lawrence I.","family":"Golbe","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00177-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6943a3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202163"},{"key":"e_1_2_9_5_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research. Conduct of Clinical Trials of Medical Products During the COVID\u201019 Public Health Emergency. In:https:\/\/www.fda.gov\/media\/136238\/download published March 2020 updated August 2021."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.10.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.15.1931"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-150549"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28094"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-140102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm032"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28470"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12243"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70088-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26580"},{"key":"e_1_2_9_17_1","unstructured":"A language and environment for statistical computing [program]. R Foundation for Statistical Computing Vienna Austria 2021."},{"key":"e_1_2_9_18_1","unstructured":"SchoenfeldD.Statistical considerations for clinical trials and scientific experiments [cited October 2021]. Available fromhttp:\/\/hedwig.mgh.harvard.edu\/sample_size\/size.html"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:23:47Z","timestamp":1786631027000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/mds.28991"],"URL":"https:\/\/doi.org\/10.1002\/mds.28991","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"2021-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}