{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:10:18Z","timestamp":1793985018776,"version":"4.8.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000887","name":"Huntington's Disease Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23\u2010NS117736"],"award-info":[{"award-number":["K23\u2010NS117736"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS055903"],"award-info":[{"award-number":["R01\u2010NS055903"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS094387"],"award-info":[{"award-number":["R01\u2010NS094387"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001671","name":"Hereditary Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/M008592\/1"],"award-info":[{"award-number":["MR\/M008592\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile\u2010onset Huntington's disease (JOHD) is a rare and particularly devastating form of Huntington's disease (HD) for which clinical diagnosis is challenging and robust outcome measures are lacking. Neurofilament light protein (NfL) in plasma has emerged as a prognostic biomarker for adult\u2010onset HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of samples and data collected between 2009 and 2020 from the Kids\u2010HD and Kids\u2010JHD studies. Plasma samples from children and young adults with JOHD, premanifest HD (preHD) mutation carriers, and age\u2010matched controls were used to quantify plasma NfL concentrations using ultrasensitive immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We report elevated plasma NfL concentrations in JOHD and premanifest HD mutation\u2010carrying children. In pediatric HD mutation carriers who were within 20\u2009years of their predicted onset and patients with JOHD, plasma NfL level was associated with caudate and putamen volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Quantifying plasma NfL concentration may assist clinical diagnosis and therapeutic trial design in the pediatric population. \u00a9 2022 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29027","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:59:19Z","timestamp":1650333559000},"page":"1526-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Neurofilament Light Protein as a Potential Blood Biomarker for Huntington's Disease in Children"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-4273","authenticated-orcid":false,"given":"Lauren M.","family":"Byrne","sequence":"first","affiliation":[{"name":"Huntington's Disease Centre, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-7268","authenticated-orcid":false,"given":"Jordan L.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"},{"name":"Department of Neurology Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-7938","authenticated-orcid":false,"given":"Filipe B.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Huntington's Disease Centre, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7490-6636","authenticated-orcid":false,"given":"Ellen","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-4679","authenticated-orcid":false,"given":"Douglas","family":"Langbehn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-1903","authenticated-orcid":false,"given":"Peggy C.","family":"Nopoulos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"},{"name":"Department of Neurology Carver College of Medicine at the University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-7887","authenticated-orcid":false,"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[{"name":"Huntington's Disease Centre, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0389-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200394"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3338"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10030155"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"e4f8606b742ef3","article-title":"The prevalence of juvenile Huntington's disease: a review of the literature and meta\u2010analysis","volume":"20","author":"Quarrell O","year":"2012","journal-title":"PLoS 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