{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:14:32Z","timestamp":1787933672914,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several pieces of evidence have shown the neurotrophic effect of erythropoietin (EPO) and its introduction in the therapeutic practice of neurological diseases. However, its usefulness in the treatment of spinocerebellar ataxia type 2 (SCA2) has not been proven despite the fact that it is endogenously reduced in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to investigate the safety, tolerability, and clinical effects of a nasally administered recombinant EPO in SCA2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four patients were enrolled in this double\u2010blind, randomized, placebo\u2010controlled, phase I\u2013II clinical trial of the nasally administered human\u2010recombinant EPO (NeuroEPO) for 6 months. The primary outcome was the change in the spinocerebellar ataxia functional index (SCAFI), while other motor, neuropsychological, and oculomotor measures were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 6\u2010month changes in SCAFI score were slightly higher in the patients allocated to NeuroEPO treatment than placebo in spite of the important placebo effect observed for this parameter. However, saccade latency was significantly decreased in the NeuroEPO group but not in placebo. The frequency and severity of adverse events were similar between both groups, without evidences of hematopoietic activity of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated the safety and tolerability of NeuroEPO in SCA2 patients after 6\u2009months of treatments and suggested a small clinical effect of this drug on motor and cognitive abnormalities, but confirmatory studies are warranted. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29045","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:37:20Z","timestamp":1653359840000},"page":"1516-1525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Erythropoietin in Spinocerebellar Ataxia Type 2: Feasibility and Proof\u2010of\u2010Principle Issues from a Randomized Controlled Study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-7683","authenticated-orcid":false,"given":"Roberto","family":"Rodriguez\u2010Labrada","sequence":"first","affiliation":[{"name":"Center for Research and Rehabilitation of Hereditary Ataxias (CIRAH)  Holgu\u00edn Cuba"},{"name":"Cuban Centre for Neurosciences  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ortega\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Center for Research and Rehabilitation of Hereditary Ataxias (CIRAH)  Holgu\u00edn Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hern\u00e1ndez Casa\u00f1a","sequence":"additional","affiliation":[{"name":"Center of Molecular Immunology (CIM)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes","family":"Santos Morales","sequence":"additional","affiliation":[{"name":"Center of Molecular Immunology (CIM)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Carmen","family":"Padr\u00f3n\u2010Estupi\u00f1an","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department \u201cVladimir I. 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