{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:41:01Z","timestamp":1772271661459,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 1172\/64\u20101"],"award-info":[{"award-number":["INST 1172\/64\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005930","name":"ASCRS Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance\u2013guided focused ultrasound of the ventral intermediate nucleus is a novel incisionless ablative treatment for essential tremor (ET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to study the structural and functional network changes induced by unilateral sonication of the ventral intermediate nucleus in ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen essential tremor patients (66.2\u2009\u00b1\u200915.4\u2009years) underwent probabilistic tractography and functional magnetic resonance imaging (MRI) during unilateral postural tremor\u2010eliciting tasks using 3\u2010T MRI before, 1 month (N\u00a0=\u00a015), and 6 months (N\u00a0=\u00a010) post unilateral sonication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tractography identified tract\u2010specific alterations within the dentato\u2010thalamo\u2010cortical tract (DTCT) affected by the unilateral lesion after sonication. Relative to the treated hand, task\u2010evoked activation was significantly reduced in contralateral primary sensorimotor cortex and ipsilateral cerebellar lobules IV\/V and VI, and vermis. Dynamic causal modeling revealed a significant decrease in excitatory drive from the cerebellum to the contralateral sensorimotor cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thalamic lesions induced by sonication induce specific functional network changes within the DTCT, notably reducing excitatory input to ipsilateral sensorimotor cortex in ET. \u00a9[2022] International Parkinson and Movement Disorder Society. \u00a9 2022 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29130","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T07:35:12Z","timestamp":1655969712000},"page":"1924-1929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-0546","authenticated-orcid":false,"given":"Emily D.R.","family":"Pohl","sequence":"first","affiliation":[{"name":"Division \u201cClinical Functional Imaging,\u201d Department of Diagnostic and Interventional Radiology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Division \u201cClinical Functional Imaging,\u201d Department of Diagnostic and Interventional Radiology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"Kobeleva","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn 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