{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:51:21Z","timestamp":1790884281086,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003350","name":"Fundaci\u00f3n Mapfre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) exhibits a high prevalence of dementia as disease severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood\u2013brain barrier (BBB) opening of cortical regions in neurodegenerative disorders. The striatum is a primary target for delivery of putative therapeutic agents in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Here, we report a prospective, single\u2010arm, nonrandomized, proof\u2010of\u2010concept, phase I clinical trial (NCT03608553 amended) in PD with dementia to test the safety and feasibility of striatal BBB opening in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven PD patients with cognitive impairment were treated for BBB opening in the posterior putamen. This was performed in two sessions separated by 2 to 4\u2009weeks, where the second session included bilateral putamina opening in 3 patients. Primary outcome measures included safety and feasibility of focal striatal BBB opening. Changes in motor and cognitive functions, magnetic resonance imaging (MRI),\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodopa (FDOPA), and \u03b2\u2010amyloid PET (positron emission tomography) images were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The procedure was feasible and well tolerated, with no serious adverse events. No neurologically relevant change in motor and cognitive (battery of neuropsychological tests) functions was recognized at follow\u2010up. MRI revealed putamen BBB closing shortly after treatment (24\u2009hours to 14\u2009days) and ruled out hemorrhagic and ischemic lesions. There was a discrete but significant reduction in \u03b2\u2010amyloid uptake in the targeted region and no change in FDOPA PET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These initial results indicate that FUS\u2010mediated striatal BBB opening is feasible and safe and therefore could become an effective tool to facilitate the delivery of putative neurorestorative molecules in PD. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29134","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T01:59:35Z","timestamp":1656467975000},"page":"2057-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Striatal\n                    <scp>Blood\u2013Brain<\/scp>\n                    Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-0031","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Pineda\u2010Pardo","sequence":"first","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"},{"name":"University CEU\u2010San Pablo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-8106","authenticated-orcid":false,"given":"Carmen","family":"Gasca\u2010Salas","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"},{"name":"University CEU\u2010San Pablo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-2883","authenticated-orcid":false,"given":"Beatriz","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"PhD Program in Neuroscience Autonoma de Madrid University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-199X","authenticated-orcid":false,"given":"Rafael","family":"Rodr\u00edguez\u2010Rojas","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"del \u00c1lamo","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-7281","authenticated-orcid":false,"given":"Ignacio","family":"Obeso","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-2863","authenticated-orcid":false,"given":"Frida","family":"Hern\u00e1ndez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4504-7967","authenticated-orcid":false,"given":"Clara","family":"Trompeta","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-013X","authenticated-orcid":false,"given":"Ra\u00fal","family":"Mart\u00ednez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-8667","authenticated-orcid":false,"given":"Michele","family":"Matarazzo","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on 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I.","family":"Montero","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-6668","authenticated-orcid":false,"given":"Guglielmo","family":"Foffani","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal) Fundaci\u00f3n Hospitales de Madrid, Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) Instituto Carlos III  Madrid Spain"},{"name":"Hospital Nacional de Parapl\u00e9jicos, SESCAM  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Toltsis","sequence":"additional","affiliation":[{"name":"Insightec Ltd  Haifa 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A","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21022-9","article-title":"Blood\u2010brain barrier opening with focused ultrasound in Parkinson's disease dementia [internet]","volume":"12","author":"Gasca\u2010salas C","year":"2021","journal-title":"Nat. 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[internet]","volume":"17","author":"Smith SM","year":"2002","journal-title":"Hum. 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