{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:33:26Z","timestamp":1783722806259,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuroferritinopathy is a rare inherited neurodegenerative disease with brain iron accumulation characterized by brain iron overload resulting in progressive movement disorders. No treatment is currently available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed conservative iron chelation with deferiprone at 30\u2009mg\/kg\/day on the disease progression with controlled periods of discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four patients with confirmed molecular diagnosis of neuroferritinopathy were given deferiprone at different stages of disease progression and with clinical and biological monitoring to control benefit and risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four patients showed slight to high improvement. In one case, we managed to stabilize disease progression for more than 11\u2009years. In another case, we were able to reverse symptoms after a few months of treatment. The earliest the treatment was started, the most efficient it was on disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conservative iron chelation should be further assessed in neuroferritinopathy. \u00a9 2022 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29145","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T02:15:55Z","timestamp":1661220955000},"page":"1948-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Conservative Iron Chelation for Neuroferritinopathy"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-5092","authenticated-orcid":false,"given":"Felix","family":"Marchand","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurogenetic Center Univ. Lille, CHU Lille, Lille Neurosciences and Cognition Inserm UMR\u2010S\u2010U1172  Lille France"},{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neurosciences and Cognition  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-2709","authenticated-orcid":false,"given":"Caroline","family":"Moreau","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurogenetic Center Univ. Lille, CHU Lille, Lille Neurosciences and Cognition Inserm UMR\u2010S\u2010U1172  Lille France"},{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neurosciences and Cognition  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Huin","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neurosciences and Cognition  Lille France"},{"name":"Department of Molecular Biology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Defebvre","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurogenetic Center Univ. Lille, CHU Lille, Lille Neurosciences and Cognition Inserm UMR\u2010S\u2010U1172  Lille France"},{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neurosciences and Cognition  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurogenetic Center Univ. Lille, CHU Lille, Lille Neurosciences and Cognition Inserm UMR\u2010S\u2010U1172  Lille France"},{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neurosciences and Cognition  Lille France"},{"name":"Department of Medical Pharmacology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.06.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.642228"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63233-3.00019-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-410502-7.00006-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.08.006"},{"issue":"1","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/brain\/awl319","article-title":"Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation","volume":"130","author":"Chinnery PF","year":"2007","journal-title":"Brain"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn274"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.061911"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30142-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00167"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5593"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9297-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24479"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03301-U"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.006"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.29145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:28:30Z","timestamp":1760963310000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/mds.29145"],"URL":"https:\/\/doi.org\/10.1002\/mds.29145","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"assertion":[{"value":"2022-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}