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In addition, a clear increase in the number of <jats:italic>HTT<\/jats:italic> CAG repeats was found among DLB and PD groups influenced by the male gender and also by the <jats:italic>APOE4<\/jats:italic> allele among DLB patients. <jats:italic>HTT<\/jats:italic> intermediate alleles' (IAs) distribution frequency increased in the MSA group compared with controls (8.8% vs. 3.9%, respectively). These differences were indeed statistically significant in the MSA group with neuropathological confirmation. Two MSA <jats:italic>HTT<\/jats:italic> CAG IAs carriers with 32 <jats:italic>HTT<\/jats:italic> CAG repeats showed isolated polyQ inclusions in pons and basal nuclei, which are two critical structures in the neurodegeneration of MSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results point to a link between <jats:italic>HTT<\/jats:italic> CAG number, <jats:italic>HTT<\/jats:italic> IAs, and expanded <jats:italic>HTT<\/jats:italic> CAG repeats with other non\u2010HD brain pathology and support the hypothesis that they can share common neurodegenerative pathways. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29153","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T12:51:00Z","timestamp":1658235060000},"page":"1841-1849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intermediate 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