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Regional <jats:sup>18<\/jats:sup>F\u2010Florzolotau binding was also expressed as standardized uptake value ratio (SUVR) to assess whether it was associated with core symptoms of MSA\u2010P after adjustment for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By visual inspection and semiquantitative SUVR comparisons, patients with MSA\u2010P showed elevated <jats:sup>18<\/jats:sup>F\u2010Florzolotau uptake in the putamen, globus pallidus, and dentate\u2014a finding that was not observed in PD. This increased signal was significantly associated with the core symptoms of MSA\u2010P. In addition, patients with MSA\u2010P with cerebellar ataxia showed an elevated <jats:sup>18<\/jats:sup>F\u2010Florzolotau uptake in the cerebellar dentate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010Florzolotau tau PET imaging findings may reflect the clinical severity of MSA\u2010P and can potentially discriminate between this condition and PD. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29159","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T08:11:50Z","timestamp":1658391110000},"page":"1915-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<scp><sup>18<\/sup>F\u2010Florzolotau<\/scp> Tau Positron Emission Tomography Imaging in Patients with Multiple System <scp>Atrophy\u2013Parkinsonian<\/scp> Subtype"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-4825","authenticated-orcid":false,"given":"Xin\u2010Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai 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Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Niu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"},{"name":"Institute of Neurology Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Zhao","family":"Ju","sequence":"additional","affiliation":[{"name":"PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang\u2010Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"PET Center, National Center for Neurological 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