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Longitudinally, we followed up the IRBD cohort by studying three time point serum samples over 26\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found sustained cross\u2010sectional and longitudinal deregulation of 12 miRNAs across the RBD continuum, including DaT\u2010negative IRBD, DaT\u2010positive IRBD, and LBD phenoconverted IRBD (let\u20107c\u20105p, miR\u201019b\u20103p, miR\u2010140, miR\u201022\u20103p, miR\u2010221\u20103p, miR\u201024\u20103p, miR\u201025\u20103p, miR\u201029c\u20103p, miR\u2010361\u20105p, miR\u2010425\u20105p, miR\u20104505, and miR\u2010451a) (false discovery rate\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.05). Age\u2010 and sex\u2010adjusted predictive modeling based on the 12 differentially expressed miRNA biosignatures discriminated IRBD and PD or DLB from controls with an area under the curve of 98% (95% confidence interval: 89\u201399%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Besides clinical diagnosis of IRBD or imaging markers such as DaT single\u2010photon emission computed tomography, specific miRNA biosignatures alone hold promise as progression biomarkers for patients with IRBD for predicting PD and DLB clinical outcomes. Further miRNA studies in other PD at\u2010risk populations, such as LRRK2 mutation asymptomatic carriers or hyposmic subjects, are warranted. \u00a9 2022 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29171","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:14:49Z","timestamp":1660356889000},"page":"2086-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Serum\n                    <scp>MicroRNAs<\/scp>\n                    Predict Isolated Rapid Eye Movement Sleep Behavior Disorder and Lewy Body Diseases"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-1908","authenticated-orcid":false,"given":"Marta","family":"Soto","sequence":"first","affiliation":[{"name":"Laboratory of Parkinson Disease and Other Neurodegenerative Movement Disorders, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)\u2010Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas (CIBERNED)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas (CIBERNED)  Barcelona Spain"},{"name":"Sleep Center, Department of Neurology, Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona  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