{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:10:53Z","timestamp":1788577853183,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It remains unclear how brain metabolic activities transform in response to dopamine deficiency in the prodromal and early phases of Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between nigrostriatal dopaminergic denervation and brain glucose metabolism in patients with isolated rapid eye movement sleep behavior disorder (iRBD) and early PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study included 28 patients with polysomnography\u2010confirmed iRBD, 24 patients with de novo PD with probable rapid eye movement sleep behavior disorder (<jats:sub>denovo<\/jats:sub>PD), and 28 healthy controls (HCs) who underwent two positron emission tomography scans with <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (all participants) and <jats:sup>18<\/jats:sup>F\u2010N\u20103\u2010fluoropropyl\u20102\u03b2\u2010carboxymethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010nortropane (except for one <jats:sub>denovo<\/jats:sub>PD patient and 15 HCs). We analyzed striatal and voxel\u2010wise whole\u2010brain glucose metabolism in relation to nigrostriatal dopaminergic integrity and comparatively investigated the whole\u2010brain metabolic connectivity among the groups. We also assessed longitudinal metabolic changes against progressive dopaminergic denervation over 4\u2009years in the iRBD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From HCs to iRBD and finally to the <jats:sub>denovo<\/jats:sub>PD, dopaminergic integrity positively correlated with metabolic activity in the caudate, whereas a negative correlation was observed in the posterior putamen. In the iRBD group, there was a metabolic increase in the inferior orbitofrontal cortex against putaminal dopaminergic denervation at baseline, but negative correlations were newly observed in the superior orbitofrontal cortex and superior frontal gyrus at the 4\u2010year follow\u2010up. The <jats:sub>denovo<\/jats:sub>PD group showed negative correlations in the cerebellum and fusiform gyrus. Intra\u2010 and inter\u2010regional metabolic connectivities in the parieto\u2010occipital cortices were enhanced in the iRBD group compared with the <jats:sub>denovo<\/jats:sub>PD and HC groups. In the iRBD group, overall metabolic connectivity was strengthened along with enhanced basal ganglia\u2010frontal connection by advancing dopaminergic denervation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest diverse trajectories of metabolic responses associated with dopaminergic denervation between individual brain areas in the prodromal and early PD stages. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29177","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:08:53Z","timestamp":1660356533000},"page":"2099-2109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Brain Metabolic Correlates of Dopaminergic Denervation in Prodromal and Early Parkinson's Disease"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-9180","authenticated-orcid":false,"given":"Ryul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Inha University Hospital, Inha University College of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Medical Research Center Seoul National University  Seoul South Korea"},{"name":"Department of Nuclear Medicine Seoul Metropolitan Government \u2013 Seoul National University Boramae Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul Metropolitan Government \u2013 Seoul National University Boramae Medical Center  Seoul South Korea"},{"name":"Memory Network 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