{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:41Z","timestamp":1787063381845,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005874","name":"Universit\u00e0 degli Studi G. d'Annunzio Chieti - Pescara","doi-asserted-by":"publisher","award":["Search4Excellence"],"award-info":[{"award-number":["Search4Excellence"]}],"id":[{"id":"10.13039\/501100005874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The high co\u2010occurrence of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients suggests overlapping pathophysiology. However, little is known about the neural correlates of SSD and their possible interactions with PD. Existing studies have shown that SSD is associated with reduced task\u2010evoked activity in the medial prefrontal cortex (mPFC), a central node of the default\u2010mode network (DMN). SSD is also associated with abnormal \u03b3\u2010aminobutyric acid (GABA) content, a marker of local inhibitory tone and regional hypoactivity, in the same area when SSD co\u2010occurs with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To disentangle the individual and shared effects of SSD and PD on mPFC neurotransmission and connectivity patterns and help disclose the neural mechanisms of comorbidity in the PD population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort included 18 PD patients with SSD (PD\u2009+\u2009SSD), 18 PD patients, 13 SSD patients who did not exhibit neurologic disorders, and 17 healthy subjects (HC). Proton magnetic resonance (MR) spectroscopy evaluated GABA levels within a volume of interest centered on the mPFC. Resting\u2010state functional MR imaging investigated the region's functional connectivity patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to HC or PD groups, the mPFC of SSD subjects exhibited higher GABA levels and connectivity. Higher mPFC connectivity involved DMN regions in SSD patients without PD and regions of the executive and attentional networks (EAN) in patients with PD comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Aberrant reconfigurations of connectivity patterns between the mPFC and the EAN are distinct features of the PD\u2009+\u2009SSD comorbidity. \u00a9 2022 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29187","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T03:18:56Z","timestamp":1661138336000},"page":"2226-2235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Altered Medial Prefrontal Connectivity in Parkinson's Disease Patients with Somatic Symptoms"],"prefix":"10.1002","volume":"37","author":[{"given":"Stefano","family":"Delli Pizzi","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging, and Clinical Sciences University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"},{"name":"Institute for Advanced Biomedical Technologies (ITAB), University G. d\u2019Annunzio of Chieti\u2010 Pescara  Chieti Italy"},{"name":"Service of Molecular Neurology, Center for Advanced Studies and Technology (CAST) University G. d\u2019Annunzio of Chieti\u2010 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Franciotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging, and Clinical Sciences University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"},{"name":"Institute for Advanced Biomedical Technologies (ITAB), University G. d\u2019Annunzio of Chieti\u2010 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Chiacchiaretta","sequence":"additional","affiliation":[{"name":"Advanced Computing Core, Center for Advanced Studies and Technology (CAST) University G. d\u2019Annunzio of Chieti \u2010 Pescara  Chieti Italy"},{"name":"Department of Advanced Technologies in Medicine &amp; Dentistry University G. d\u2019Annunzio of Chieti \u2010 Pescara  Chieti 66100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging, and Clinical Sciences University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"},{"name":"Institute for Advanced Biomedical Technologies (ITAB), University G. d\u2019Annunzio of Chieti\u2010 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Edden","sequence":"additional","affiliation":[{"name":"Russell H. 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