{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T22:04:28Z","timestamp":1785103468339,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance\u2013guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug\u2010resistant tremor in Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early\u2010stage tremor\u2010dominant PD may prevent an increase in dopaminergic medication 6\u2009months after treatment compared with matched PD control subjects on standard medical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled patients with early\u2010stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD\u2010FUS) and patients treated with oral dopaminergic therapy (PD\u2010ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12\u00a0months after thalamotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 10 patients in the PD\u2010FUS group and 20 patients in the PD\u2010ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD\u2010ODT group 6\u2009months after thalamotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In early\u2010stage tremor\u2010dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. \u00a9 2022 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29200","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:34:14Z","timestamp":1661751254000},"page":"2289-2295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Magnetic Resonance\u2013Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early\u2010Stage Tremor\u2010Dominant Parkinson's Disease: A Pilot Study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-5367","authenticated-orcid":false,"given":"Nico","family":"Golfr\u00e8 Andreasi","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences Parkinson and Movement Disorders Unit  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-1939","authenticated-orcid":false,"given":"Roberto","family":"Cilia","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences Parkinson and Movement Disorders Unit  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-1035","authenticated-orcid":false,"given":"Luigi 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