{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:42:06Z","timestamp":1792168926460,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Measures of step variability and body sway during gait have shown to correlate with clinical ataxia severity in several cross\u2010sectional studies. However, to serve as a valid progression biomarker, these gait measures have to prove their sensitivity to robustly capture longitudinal change, ideally within short time frames (eg, 1\u2009year). We present the first multicenter longitudinal gait analysis study in spinocerebellar ataxias. We performed a combined cross\u2010sectional (n\u00a0=\u00a028) and longitudinal (1\u2010year interval, n\u00a0=\u00a017) analysis in Spinocerebellar Ataxia type 3 subjects (including seven preataxic mutation carriers). Longitudinal analysis showed significant change in gait measures between baseline and 1\u2010year follow\u2010up, with high effect sizes (stride length variability:\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.01, effect size r\n                    <jats:sub>prb<\/jats:sub>\n                    \u00a0=\u00a00.66; lateral sway:\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.007, r\n                    <jats:sub>prb<\/jats:sub>\n                    \u00a0=\u00a00.73). Sample size estimation for lateral sway indicates a required cohort size of n\u00a0=\u00a043 for detecting a 50% reduction of natural progression, compared with n\u00a0=\u00a0240 for the clinical ataxia score Scale for the Assessment and Rating of Ataxia (SARA). These measures thus present promising motor biomarkers for upcoming interventional studies. \u00a9 2022 The Authors.\n                    <jats:italic>Movement Disorders<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.29206","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T04:16:22Z","timestamp":1661919382000},"page":"2295-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Digital Gait Biomarkers Allow to Capture 1\u2010Year Longitudinal Change in Spinocerebellar Ataxia Type 3"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1537-1336","authenticated-orcid":false,"given":"Winfried","family":"Ilg","sequence":"first","affiliation":[{"name":"Section Computational Sensomotorics Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Section Computational Sensomotorics Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"van Gaalen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-2667","authenticated-orcid":false,"given":"Holger","family":"Hengel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research and Centre of Neurology  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina R.","family":"Vogt","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Hennes","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-1616","authenticated-orcid":false,"given":"Bart","family":"van de Warrenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klockgether","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-5025","authenticated-orcid":false,"given":"Ludger","family":"Sch\u00f6ls","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research and Centre of Neurology  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research and Centre of Neurology  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ESMI 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