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However, spontaneous genetic mutations have not been linked to the pathological hallmarks of PD in non\u2010human vertebrates.<\/jats:p><\/jats:sec>Objective<\/jats:title>To describe the genetic and pathological findings of three Yellow\u2010crowned parrot (Amazona ochrocepahala<\/jats:italic>) siblings with a severe and rapidly progressive neurological phenotype.<\/jats:p><\/jats:sec>Methods<\/jats:title>The phenotype of the three parrots included severe ataxia, rigidity, and tremor, while their parents were phenotypically normal. Tests to identify avian viral infections and brain imaging studies were all negative. Due to their severe impairment, they were all euthanized at age 3\u2009months and their brains underwent neuropathological examination and proteasome activity assays. Whole genome sequencing (WGS) was performed on the three affected parrots and their parents.<\/jats:p><\/jats:sec>Results<\/jats:title>The brains of affected parrots exhibited neuronal loss, spongiosis, and widespread Lewy body\u2010like inclusions in many regions including the midbrain, basal ganglia, and neocortex. Proteasome activity was significantly reduced in these animals compared to a control (P<\/jats:italic>\u2009<\u20090.05). WGS identified a single homozygous missense mutation (p.V559L) in a highly conserved amino acid within the pleckstrin homology (PH) domain of the calcium\u2010dependent secretion activator 2 (CADPS2<\/jats:italic>) gene.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our data suggest that a homozygous mutation in the CADPS2<\/jats:italic> gene causes a severe neurodegenerative phenotype with Lewy body\u2010like pathology in parrots. Although CADPS2<\/jats:italic> variants have not been reported to cause PD, further investigation of the gene might provide important insights into the pathophysiology of Lewy body disorders. \u00a9 2022 The Authors. Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29211","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T04:50:07Z","timestamp":1662785407000},"page":"2345-2354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Homozygous CADPS2<\/i><\/scp> Mutations Cause Neurodegenerative Disease with Lewy Body\u2010like Pathology in Parrots"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-8363","authenticated-orcid":false,"given":"Oswaldo","family":"Lorenzo\u2010Betancor","sequence":"first","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System Seattle Washington USA"},{"name":"Department of Neurology University of Washington School of Medicine Seattle Washington 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