{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:34Z","timestamp":1786978174075,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Italian Neuroscience network (RIN)"],"award-info":[{"award-number":["Italian Neuroscience network (RIN)"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["fondi per la ricerca corrente 2019\/2020"],"award-info":[{"award-number":["fondi per la ricerca corrente 2019\/2020"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004702","name":"University of Genoa","doi-asserted-by":"publisher","award":["Curiosity Grant to M.P."],"award-info":[{"award-number":["Curiosity Grant to M.P."]}],"id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of \u03b1\u2010synucleinopathies. Reliable biomarkers are needed to predict phenoconversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to derive and validate a brain glucose metabolism pattern related to phenoconversion in iRBD (iRBDconvRP) using spatial covariance analysis (Scaled Subprofile Model and Principal Component Analysis [SSM\u2010PCA]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010six consecutive iRBD patients (70\u2009\u00b1\u20096\u2009years, 15 women) were enrolled in two centers and prospectively evaluated to assess phenoconversion (30 converters, 73\u2009\u00b1\u20096\u2009years, 14 Parkinson's disease and 16 dementia with Lewy bodies, follow\u2010up time: 21\u2009\u00b1\u200914\u00a0months; 46 nonconverters, 69\u2009\u00b1\u20096\u2009years, follow\u2010up time: 33\u2009\u00b1\u200919\u00a0months). All patients underwent [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG\u2010PET (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose positron emitting tomography) to investigate brain glucose metabolism at baseline. SSM\u2010PCA was applied to obtain the iRBDconvRP; nonconverter patients were considered as the reference group. Survival analysis and Cox regression were applied to explore prediction power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>First, we derived and validated two distinct center\u2010specific iRBDconvRP that were comparable and significantly able to predict phenoconversion. Then, SSM\u2010PCA was applied to the whole set, identifying the iRBDconvRP. The iRBDconvRP included positive voxel weights in cerebellum; brainstem; anterior cingulate cortex; lentiform nucleus; and middle, mesial temporal, and postcentral areas. Negative voxel weights were found in posterior cingulate, precuneus, middle frontal gyrus, and parietal areas. Receiver operating characteristic analysis showed an area under the curve of 0.85 (sensitivity: 87%, specificity: 72%), discriminating converters from nonconverters. The iRBDconvRP significantly predicted phenoconversion (hazard ratio: 7.42, 95% confidence interval: 2.6\u201321.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We derived and validated an iRBDconvRP to efficiently discriminate converter from nonconverter iRBD patients. [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG\u2010PET pattern analysis has potential as a phenoconversion biomarker in iRBD patients. \u00a9 2022 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29236","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T07:50:49Z","timestamp":1664783449000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Derivation and Validation of a Phenoconversion\u2010Related Pattern in Idiopathic Rapid Eye Movement Behavior Disorder"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-5830","authenticated-orcid":false,"given":"Pietro","family":"Mattioli","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-7940","authenticated-orcid":false,"given":"Beatrice","family":"Orso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology University of Genoa  Genoa Italy"},{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC, Location VuMC, Amsterdam Neuroscience  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"Sleep Medicine Center, Neurology Unit University Hospital \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fam\u00e0","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico S. 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