{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:01:15Z","timestamp":1791849675620,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["Fund To Retain Clinician Scientist"],"award-info":[{"award-number":["Fund To Retain Clinician Scientist"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014427","name":"Dystonia Coalition","doi-asserted-by":"publisher","award":["NS065701"],"award-info":[{"award-number":["NS065701"]}],"id":[{"id":"10.13039\/100014427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014427","name":"Dystonia Coalition","doi-asserted-by":"publisher","award":["TR001456"],"award-info":[{"award-number":["TR001456"]}],"id":[{"id":"10.13039\/100014427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014427","name":"Dystonia Coalition","doi-asserted-by":"publisher","award":["NS116025"],"award-info":[{"award-number":["NS116025"]}],"id":[{"id":"10.13039\/100014427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","award":["Clinical Fellowship Training Program"],"award-info":[{"award-number":["Clinical Fellowship Training Program"]}],"id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002554"],"award-info":[{"award-number":["KL2TR002554"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TR 001456"],"award-info":[{"award-number":["TR 001456"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS065701"],"award-info":[{"award-number":["NS065701"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS116025"],"award-info":[{"award-number":["NS116025"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Writer's cramp (WC) dystonia is a rare disease that causes abnormal postures during the writing task. Successful research studies for WC and other forms of dystonia are contingent on identifying sensitive and specific measures that relate to the clinical syndrome and achieve a realistic sample size to power research studies for a rare disease. Although prior studies have used writing kinematics, their diagnostic performance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic performance of automated measures that distinguish subjects with WC from healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 21 subjects with WC and 22 healthy volunteers performed a sentence\u2010copying assessment on a digital tablet using kinematic and hand recognition softwares. The sensitivity and specificity of automated measures were calculated using a logistic regression model. Power analysis was performed for two clinical research designs using these measures. The test and retest reliability of select automated measures was compared across repeat sentence\u2010copying assessments. Lastly, a correlational analysis with subject\u2010 and clinician\u2010rated outcomes was performed to understand the clinical meaning of automated measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 23 measures analyzed, the measures of word legibility and peak accelerations distinguished subjects with WC from healthy volunteers with high sensitivity and specificity and demonstrated smaller sample sizes suitable for rare disease studies, and the kinematic measures showed high reliability across repeat visits, while both word legibility and peak accelerations measures showed significant correlations with the subject\u2010 and clinician\u2010rated outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Novel automated measures that capture key aspects of the disease and are suitable for use in clinical research studies of WC dystonia were identified. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29237","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T08:40:55Z","timestamp":1665650455000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-6459","authenticated-orcid":false,"given":"Noreen","family":"Bukhari\u2010Parlakturk","sequence":"first","affiliation":[{"name":"Department of Neurology Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Institute for Brain Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein R.","family":"Al\u2010Khalidi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakthi","family":"Unnithan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce En\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Georgetown University Medical School  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-3119","authenticated-orcid":false,"given":"Pichet","family":"Termsarasab","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence G.","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Calakos","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Institute for Brain Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Neurobiology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.09.024"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1094"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207729"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870030302"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070094"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2006.05.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.1.73"},{"key":"e_1_2_9_10_1","first-page":"172","article-title":"Botulinum toxin in writer's cramp: objective response evaluation in 31 patients","volume":"61","author":"Wissel J","year":"1996","journal-title":"J Neurol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21294"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2010.04.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.529"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.07.426"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2015.00286","article-title":"Anodal transcranial direct current stimulation to the cerebellum improves handwriting and cyclic drawing kinematics in focal hand dystonia","volume":"9","author":"Bradnam LV","year":"2015","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.jht.2004.04.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2015.00385","article-title":"Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia","volume":"9","author":"Kimberley TJ","year":"2015","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-9457(84)90011-3"},{"key":"e_1_2_9_19_1","first-page":"179","volume-title":"The Psychology of Written Language: Development and Educational Perspectives","author":"Thomassen AJ","year":"1983"},{"key":"e_1_2_9_20_1","unstructured":"TeulingsH RomeroDH.Submovement analysis in learning cursive handwriting or block print.TeulingsHLandVan GemmertAWA(Eds.) Proceedings of the 11th Conference of the International Graphonomics Society (IGS2003) 2\u20103 November2003 Scottsdale AZ."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-9457(91)90010-U"},{"key":"e_1_2_9_22_1","unstructured":"Neuroscript.Neuroscript MovAlyzeR Help: Viewing Trials. [cited2022Apr 9]. Available from:https:\/\/www.neuroscript.net\/help\/viewingtrials.html"},{"key":"e_1_2_9_23_1","unstructured":"MuellerR.OneNote: Optical character recognition \u2010 TechNet articles \u2010 United States (English) \u2010 TechNet Wiki. Microsoft Corporation.2018[cited 2022 Apr 9]. Available from:https:\/\/social.technet.microsoft.com\/wiki\/contents\/articles\/20937.onenote-optical-character-recognition\/history.aspx"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.3012542"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6507"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh315"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.29237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:25:15Z","timestamp":1760970315000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/mds.29237"],"URL":"https:\/\/doi.org\/10.1002\/mds.29237","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.03.02.21252036","asserted-by":"object"}]},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"2022-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}