{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:50:57Z","timestamp":1792144257436,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009938","name":"KHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009938","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010360","name":"Marie og M.B. Richters Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004209","name":"Otto M\u00f8nsteds Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010103","name":"Vera og Carl Johan Michaelsens Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021851","name":"William Demant Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated rapid\u2010eye\u2010movement sleep behavior disorder (iRBD) is in most cases a prodrome of neurodegenerative synucleinopathies, affecting 1% to 2% of middle\u2010aged and older adults; however, accurate ambulatory diagnostic methods are not available. Questionnaires lack specificity in nonclinical populations. Wrist actigraphy can detect characteristic features in individuals with RBD; however, high\u2010frequency actigraphy has been rarely used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to develop a machine learning classifier using high\u2010frequency (1\u2010second resolution) actigraphy and a short patient survey for detecting iRBD with high accuracy and precision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The method involved analysis of home actigraphy data (for seven nights and more) and a nine\u2010item questionnaire (RBD Innsbruck inventory and three synucleinopathy prodromes of subjective hyposmia, constipation, and orthostatic dizziness) in a data set comprising 42 patients with iRBD, 21 sleep clinic patients with other sleep disorders, and 21 community controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The actigraphy classifier achieved 95.2% (95% confidence interval [CI]: 88.3\u201398.7) sensitivity and 90.9% (95% CI: 82.1\u201395.8) precision. The questionnaire classifier achieved 90.6% accuracy and 92.7% precision, exceeding the performance of the Innsbruck RBD Inventory and prodromal questionnaire alone. Concordant predictions between actigraphy and questionnaire reached a specificity and precision of 100% (95% CI: 95.7\u2013100.0) with 88.1% sensitivity (95% CI: 79.2\u201394.1) and outperformed any combination of actigraphy and a single question on RBD or prodromal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Actigraphy detected iRBD with high accuracy in a mixed clinical and community cohort. This cost\u2010effective fully remote procedure can be used to diagnose iRBD in specialty outpatient settings and has potential for large\u2010scale screening of iRBD in the general population. \u00a9 2022 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29249","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T01:29:05Z","timestamp":1666142945000},"page":"82-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Ambulatory Detection of Isolated Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder Combining Actigraphy and Questionnaire"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-0929","authenticated-orcid":false,"given":"Andreas","family":"Brink\u2010Kjaer","sequence":"first","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"},{"name":"Department of Clinical Neurophysiology Danish Center for Sleep Medicine  Rigshospitalet Denmark"},{"name":"Department of Psychiatry and Behavioral Sciences, Stanford Center for Sleep Sciences and Medicine Stanford University  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford Center for Sleep Sciences and Medicine Stanford University  Redwood City California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahid","family":"Hekmat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford Center for Sleep Sciences and Medicine Stanford University  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cahuas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford Center for Sleep Sciences and Medicine Stanford University  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Langston","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford 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