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Recent work suggests that the accumulation of oxidized dopamine and neuromelanin mediate the convergence of mitochondrial and lysosomal dysfunction in patient\u2010derived neurons. In addition, the expression of human tyrosinase in mouse SNpc led to the formation of neuromelanin resulting in the degeneration of nigral dopaminergic neurons, further highlighting the importance of neuromelanin in PD. The potential role of neuromelanin in PD pathogenesis has been supported by epidemiological observations, whereby individuals with lighter pigmentation or cutaneous malignant melanoma exhibit higher incidence of PD. Because neuromelanin and melanin share many functional characteristics and overlapping biosynthetic pathways, it has been postulated that genes involved in skin pigmentation and melanin formation may play a role in the susceptibility of vulnerable midbrain dopaminergic neurons to neurodegeneration. Here, we highlight potential mechanisms that may explain the link between skin pigmentation and PD, focusing on the role of skin pigmentation genes in the pathogenesis of PD. We also discuss the importance of genetic ancestry in assessing the contribution of pigmentation\u2010related genes to risk of PD. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.29260","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T09:24:55Z","timestamp":1667985895000},"page":"185-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Talia","family":"Krainc","sequence":"first","affiliation":[{"name":"Department of Anthropology Princeton University  Princeton New Jersey USA"},{"name":"Ken and Ruth Davee Department of Neurology Northwestern University, Feinberg School of Medicine  Chicago Illinois 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