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In addition, HD macaques displayed significant glucose hypometabolism throughout the cortico\u2010basal ganglia network (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>[<jats:sup>18<\/jats:sup>F]Fallypride and [<jats:sup>18<\/jats:sup>F]FDG are PET imaging biomarkers of mHTT\u2010mediated disease progression that can be used as noninvasive outcome measures in future therapeutic studies with this AAV\u2010mediated HD macaque model. \u00a9 2022 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29271","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T01:32:35Z","timestamp":1671672755000},"page":"143-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reduced <scp>D<sub>2<\/sub><\/scp>\/<scp>D<sub>3<\/sub><\/scp> Receptor Binding and Glucose Metabolism 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