{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:41:37Z","timestamp":1787838097803,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","award":["Earlystim"],"award-info":[{"award-number":["Earlystim"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The EARLYSTIM trial demonstrated for Parkinson's disease patients with early motor complications that deep brain stimulation of the subthalamic nucleus (STN\u2010DBS) and best medical treatment (BMT) was superior to BMT alone.<\/jats:p><\/jats:sec>Objective<\/jats:title>This prospective, ancillary study on EARLYSTIM compared changes in blinded speech intelligibility assessment between STN\u2010DBS and BMT over 2\u2009years, and secondary outcomes included non\u2010speech oral movements (maximum phonation time [MPT], oral diadochokinesis), physician\u2010 and patient\u2010reported assessments.<\/jats:p><\/jats:sec>Methods<\/jats:title>STN\u2010DBS (n\u00a0=\u00a0102) and BMT (n\u00a0=\u00a099) groups underwent assessments on\/off<\/jats:italic> medication at baseline and 24\u00a0months (in four conditions: on\/off<\/jats:italic> medication, ON\/OFF stimulation\u2014for STN\u2010DBS). Words and sentences were randomly presented to blinded listeners, and speech intelligibility rate was measured. Statistical analyses compared changes between the STN\u2010DBS and BMT groups from baseline to 24\u00a0months.<\/jats:p><\/jats:sec>Results<\/jats:title>Over the 2\u2010year period, changes in speech intelligibility and MPT, as well as patient\u2010reported outcomes, were not different between groups, either off<\/jats:italic> or on<\/jats:italic> medication or OFF or ON stimulation, but most outcomes showed a nonsignificant trend toward worsening in both groups. Change in oral diadochokinesis was significantly different between STN\u2010DBS and BMT groups, on<\/jats:italic> medication and OFF STN\u2010DBS, with patients in the STN\u2010DBS group performing slightly worse than patients under BMT only. A signal for clinical worsening with STN\u2010DBS was found for the individual speech item of the Unified Parkinson's Disease Rating Scale, Part III.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>At this early stage of the patients' disease, STN\u2010DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient\u2010reported communication, as observed in studies of advanced Parkinson's Disease. \u00a9 2022 The Authors. Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29282","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:49:22Z","timestamp":1670050162000},"page":"212-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Results of a Randomized Clinical Trial of Speech After Early Neurostimulation in Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-4787","authenticated-orcid":false,"given":"Serge","family":"Pinto","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Univ CNRS, LPL Aix\u2010en\u2010Provence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Nebel","sequence":"additional","affiliation":[{"name":"Department of Neurology University 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