{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:17:46Z","timestamp":1792113466109,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n GBA1<\/jats:italic>\n variants are among the most common genetic risk factors for Parkinson's disease (PD).\n GBA1<\/jats:italic>\n variants can be classified into three categories based on their role in Gaucher's disease (GD) or PD: severe, mild, and risk variant (for PD).\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This review aims to generate and share a comprehensive database for\n GBA1<\/jats:italic>\n variants reported in PD to support future research and clinical trials.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed a literature search for all\n GBA1<\/jats:italic>\n variants that have been reported in PD. The data have been standardized and complemented with variant classification, odds ratio if available, and other data.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found 371\n GBA1<\/jats:italic>\n variants reported in PD: 22 mild, 84 severe, 3 risk variants, and 262 of unknown status. We created a browser containing up\u2010to\u2010date information on these variants (\n https:\/\/pdgenetics.shinyapps.io\/GBA1Browser\/<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The classification and browser presented in this work should inform and support basic, translational, and clinical research on\n GBA1<\/jats:italic>\n \u2010PD. \u00a9 2023 International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.29314","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T09:15:05Z","timestamp":1672823705000},"page":"489-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Classification of\n \n GBA1<\/i>\n <\/scp>\n Variants in Parkinson's Disease: The\n \n GBA1<\/i>\n \u2010PD\n <\/scp>\n Browser"],"prefix":"10.1002","volume":"38","author":[{"given":"Sitki Cem","family":"Parlar","sequence":"first","affiliation":[{"name":"Department of Human Genetics McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"The Neuro (Montreal Neurological Institute\u2010Hospital), McGill University Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis P.","family":"Grenn","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonggeol Jeffrey","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging Bethesda Maryland USA"},{"name":"Preventive Neurology Unit, Centre for Prevention Diagnosis and Detection Wolfson Institute of Population Health, Queen Mary University of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-8111","authenticated-orcid":false,"given":"Cornelis","family":"Baluwendraat","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging Bethesda Maryland USA"},{"name":"Center for Alzheimer's and Related Dementias National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-234X","authenticated-orcid":false,"given":"Ziv","family":"Gan\u2010Or","sequence":"additional","affiliation":[{"name":"Department of Human Genetics McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"The Neuro (Montreal Neurological Institute\u2010Hospital), McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University Montr\u00e9al Qu\u00e9bec 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